ArticleProceedings of the National Academy of Sciences of the United States of America2005
The anti-tetanus immune response of neonatal mice is augmented by retinoic acid combined with polyriboinosinic:polyribocytidylic acid.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Men with low vitamin A stores respond adequately to primary yellow fever and secondary tetanus toxoid vaccination.The Journal of nutrition · 2008Trial
- Vitamin A Positively Correlates with Secretory Immunoglobulin A: A Cross-Sectional Study in Omicron COVID-19 Outpatients.Journal of clinical medicine · 2024Article
- Article
- Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity.Journal of nutritional science · 2022Article
- Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.Reviews in medical virology · 2021Review
- Multiple Vaccinations and the Enigma of Vaccine Injury.Vaccines · 2020Review
- Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.Cell reports · 2020Article
- TH1/TH2 chemokines/cytokines profile in rats treated with tetanus toxoid andSaudi journal of biological sciences · 2019Article
- Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases.Mediators of inflammation · 2018Review
- Direct and indirect vitamin A supplementation strategies result in different plasma and tissue retinol kinetics in neonatal rats.Journal of lipid research · 2016Article
- Neonatal Vaccination: Challenges and Intervention Strategies.Neonatology · 2016Review
- Potential for use of retinoic acid as an oral vaccine adjuvant.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice.Hepatology (Baltimore, Md.) · 2014Article
- Article
- Retinol kinetics in unsupplemented and vitamin A-retinoic acid supplemented neonatal rats: a preliminary model.Journal of lipid research · 2014Article
- β-Carotene Biosynthesis in Probiotic Bacteria.Probiotics and antimicrobial proteins · 2013Article
- Vitamin A and retinoic acid in T cell-related immunity.The American journal of clinical nutrition · 2012Review
- Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice.The Journal of nutrition · 2012Article
- Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.Journal of medicinal chemistry · 2012Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neonates are highly susceptible to infectious diseases and, in general, respond poorly to conventional vaccines due to immaturity of the immune system. In the present study, we hypothesized that the anti-tetanus toxoid (TT) vaccine response of neonatal mice could be enhanced by retinoic acid (RA), a bioactive retinoid, and polyriboinosinic:polyribocytidylic acid (PIC), an inducer of IFN. Early-life treatments with RA and/or PIC were well tolerated and stimulated both primary anti-TT IgG production in infancy and the memory response in adulthood. TT-specific lymphocyte proliferation and type 1/type 2 cytokine production were also significantly augmented. In addition, RA and PIC modulated the maturation and/or differentiation of neonatal B cells, natural killer (NK)/NKT cells, and antigen-presenting cells. Although RA alone increased the neonatal anti-TT antibody response, it selectively increased anti-TT IgG1 and IL-5, resulting in a skewed type 2 response. PIC, a potent adjuvant in adult mice, elevated neonatal anti-TT IgG as well as all IgG isotypes (IgG1, IgG2a, and IgG2b) and induced TT-specific IFN-gamma, an important type 1 cytokine; however, PIC alone failed to benefit the memory response. The combination of RA plus PIC was more potent than either agent alone in elevating primary and secondary anti-TT IgG responses as well as IgG isotypes. Moreover, RA plus PIC increased TT-specific IFN-gamma and IL-5, suggesting the combination effectively promoted both type 1 and type 2 responses in neonatal mice. Thus, RA combined with PIC, a nutritional-immunological intervention, seems promising as an adjuvant for early-life vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.