ArticleThe Journal of cell biology2005
Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Structure determination and dual targeting of a plant TACO1 identifies its ancient role as an organelle translation regulator.bioRxiv : the preprint server for biology · 2026Article
- Molecular machineries and pathways of mitochondrial protein transport.Nature reviews. Molecular cell biology · 2025Review
- Protein insertion into the inner membrane of mitochondria: routes and mechanisms.FEBS open bio · 2024Review
- The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria.EMBO reports · 2024Article
- Crosstalk between Mitochondrial Protein Import and Lipids.International journal of molecular sciences · 2022Review
- Dissecting the molecular mechanisms of mitochondrial import and maturation of peroxiredoxins from yeast and mammalian cells.Biophysical reviews · 2021Review
- Constraint-based modeling of yeast mitochondria reveals the dynamics of protein import and iron-sulfur cluster biogenesis.iScience · 2021Article
- Protein import in mitochondria biogenesis: guided by targeting signals and sustained by dedicated chaperones.RSC advances · 2021Review
- Axonal Transport and Mitochondrial Function in Neurons.Frontiers in cellular neuroscience · 2019Review
- Antibodies to biotin enable large-scale detection of biotinylation sites on proteins.Nature methods · 2017Article
- Sorting of SEC translocase SCY components to different membranes in chloroplasts.Journal of experimental botany · 2017Article
- Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins.Cell metabolism · 2016Article
- The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.EMBO reports · 2016Review
- Role of membrane contact sites in protein import into mitochondria.Protein science : a publication of the Protein Society · 2015Review
- Dissecting stop transfer versus conservative sorting pathways for mitochondrial inner membrane proteins in vivo.The Journal of biological chemistry · 2013Article
- Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.The Journal of biological chemistry · 2012Article
- Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.The Journal of cell biology · 2012Article
- Biogenesis of the cytochrome bc(1) complex and role of assembly factors.Biochimica et biophysica acta · 2012Review
- TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane.The EMBO journal · 2011Article
- Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.The EMBO journal · 2010Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most inner membrane proteins of mitochondria are synthesized in the cytosol and reach the inner membrane using one of two alternative sorting pathways. On the stop transfer route, proteins are arrested during import at the level of the inner membrane. The conservative sorting pathway involves translocation through the inner membrane and insertion from the matrix. It is unclear how the translocase of the inner membrane 23 protein translocation machinery differentiates between the two classes of proteins. Here we show that proline residues in hydrophobic stretches strongly disfavor the translocation arrest of transmembrane domains (TMDs) and favor the transfer of preproteins to the matrix. We propose that proline residues, together with the hydrophobicity of the TMD and the presence of charged residues COOH-terminally flanking the TMD, are determinants of the intramitochondrial sorting of inner membrane proteins.
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