ArticleGenetics2006
GC-biased segregation of noncoding polymorphisms in Drosophila.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Evolution of GC-biased gene conversion by natural selection.Genetics · 2025Article
- Biased Gene Conversion Constrains Adaptation inGenetics · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Distinguishing Among Evolutionary Forces Acting on Genome-Wide Base Composition: Computer Simulation Analysis of Approximate Methods for Inferring Site Frequency Spectra of Derived Mutations.G3 (Bethesda, Md.) · 2018Article
- Variation in the Intensity of Selection on Codon Bias over Time Causes Contrasting Patterns of Base Composition Evolution in Drosophila.Genome biology and evolution · 2017Article
- Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.Journal of molecular evolution · 2016Article
- Selection Against Maternal microRNA Target Sites in Maternal Transcripts.G3 (Bethesda, Md.) · 2015Article
- Nucleosomes shape DNA polymorphism and divergence.PLoS genetics · 2014Article
- Differential strengths of positive selection revealed by hitchhiking effects at small physical scales in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- Stabilizing selection, purifying selection, and mutational bias in finite populations.Genetics · 2013Article
- Drosophila functional elements are embedded in structurally constrained sequences.PLoS genetics · 2013Article
- Should Y stay or should Y go: the evolution of non-recombining sex chromosomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Review
- Selection on codon usage and base composition in Drosophila americana.Biology letters · 2012Article
- The many landscapes of recombination in Drosophila melanogaster.PLoS genetics · 2012Article
- Population genomic analysis of base composition evolution in Drosophila melanogaster.Genome biology and evolution · 2012Article
- Evidence for widespread GC-biased gene conversion in eukaryotes.Genome biology and evolution · 2012Article
- Article
- The surprising negative correlation of gene length and optimal codon use--disentangling translational selection from GC-biased gene conversion in yeast.BMC evolutionary biology · 2011Article
- The effects of demography and linkage on the estimation of selection and mutation parameters.Genetics · 2010Article
- Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.Genetics · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of base composition evolution in Drosophila has been achieved mostly through the analysis of coding sequences. Third codon position GC content, however, is influenced by both neutral forces (e.g., mutation bias) and natural selection for codon usage optimization. In this article, large data sets of noncoding DNA sequence polymorphism in D. melanogaster and D. simulans were gathered from public databases to try to disentangle these two factors-noncoding sequences are not affected by selection for codon usage. Allele frequency analyses revealed an asymmetric pattern of AT vs. GC noncoding polymorphisms: AT --> GC mutations are less numerous, and tend to segregate at a higher frequency, than GC --> AT ones, especially at GC-rich loci. This is indicative of nonstationary evolution of base composition and/or of GC-biased allele transmission. Fitting population genetics models to the allele frequency spectra confirmed this result and favored the hypothesis of a biased transmission. These results, together with previous reports, suggest that GC-biased gene conversion has influenced base composition evolution in Drosophila and explain the correlation between intron and exon GC content.
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Registered trials
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