Evidence map›Paper›PMID 16157477›Full record

ArticleInternational journal of antimicrobial agents2005

Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro.

A Mayr, G Hinterberger, M P Dierich, C Lass-Flörl

Open access · greenAbstract read
In one paragraph

Article in International journal of antimicrobial agents, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 36 citations in OpenAlex.

  1. Exposure toPeerJ · 2025
    Article
  2. Diallyl Disulfide (DADS) Ameliorates IntestinalFrontiers in cellular and infection microbiology · 2021
    Article
  3. Article
  4. To Be or Not to Be a Pathogen:Frontiers in immunology · 2019
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A MayrDepartment of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria. astrid.mayr@uibk.ac.at
G Hinterberger
M P Dierich
C Lass-Flörl
Innsbruck Medical University · AT

Funding

Austrian Science Fund FWF P 17484
6 · The paper itself

Abstract

In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118-0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.

Indexed as

Aspartic Acid EndopeptidasesCandida albicansFree Radical ScavengersHyphaeMicrobial Sensitivity TestsPhospholipasesSerotoninVirulence FactorsAspartic Acid EndopeptidasesFree Radical ScavengersPhospholipasesSerotoninVirulence Factors

Identifiers

PMID16157477
PMCPMC2980867
OpenAlexW2089428179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.