ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2005
Community-acquired pathogens associated with prolonged coughing in children: a prospective cohort study.
Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Consensus statement on the evaluation and therapy of chronic cough in children].Wiener klinische Wochenschrift · 2014Guideline
- The prevalence and role of human respiratory syncytial virus in pediatric respiratory tract infections: a systematic review and meta-analysis of global data.EClinicalMedicine · 2026Article
- Prevalence of Influenza Viruses A and B, Adenovirus, Respiratory Syncytial Virus, and Human Metapneumonia Viruses among Children with Acute Respiratory Tract Infection.Advances in virology · 2024Article
- Pertussis and parapertussis in children and adults with a persistent cough: an observational study.Infection · 2018Observational
- Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen.BMC infectious diseases · 2017Article
- Prolonged Cough in Pediatric Population First Line Care, Belgian Guidelines.The open respiratory medicine journal · 2017Article
- Pertussis Accompanying Recent Mycoplasma Infection in a 10-Year-Old Girl.Infection & chemotherapy · 2015Article
- [Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014Article
- Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort study.BMJ (Clinical research ed.) · 2014Article
- Dual infection with Bordetella pertussis and Mycoplasma pneumoniae in three infants: case reports.Infection · 2012Article
- The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery.Medicinal research reviews · 2011Review
- Seroprevalence of pertussis among Danish patients with cough of unknown etiology.Clinical and vaccine immunology : CVI · 2010Article
- Human rhinoviruses: the cold wars resume.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Review
- Whooping cough in general practice.BMJ (Clinical research ed.) · 2006Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 2-year prospective study was performed of children with prolonged coughing to investigate the frequency of different respiratory pathogens, the rate of mixed infections, and possible differences in severity of disease between single and mixed infections. Sera from 135 children (136 episodes of prolonged coughing lasting 1-6 weeks) were tested for antibodies to different viruses and bacteria. Swabs were taken for culture and PCR to detect different viral and bacterial pathogens. One or more pathogens were found in 91 (67%) patients. One infectious agent was found in 49 (36%) patients, two agents in 35 (26%) patients, and more than two agents in seven (5%) patients. The most frequent pathogens encountered were rhinovirus (n = 43; 32%), Bordetella pertussis (n = 23; 17%) and respiratory syncytial virus (n = 15; 11%). The most frequent mixed infection was B. pertussis and rhinovirus (n = 14; 10%). No significant differences in clinical symptoms were observed between patients with or without pathogens; however, patients with mixed infections were significantly older. There was a strong seasonal influence on the number of infections, but not on the number of mixed infections. In children with prolonged coughing, there was a high frequency of mixed infections regardless of the season. However, mixed infection was not associated with increased disease severity. No clinical symptoms were found that allowed discrimination between specific pathogens.
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