ReviewAnnual review of microbiology2005
Biogenesis, architecture, and function of bacterial type IV secretion systems.
Review in Annual review of microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 333 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
333 citing papers in PubMed, 619 citations in OpenAlex.
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- Fighting the invader: strategies against intracellular bacteria.Frontiers in pharmacology · 2026Review
- Transmembrane effector substrates of type IV secretion systems: mechanisms of secretion and insertion into host cell membranes.microLife · 2026Review
- Genomic Drivers of Biofilm Formation inMicroorganisms · 2025Article
- A catalog of proteins released fromMicrobiology spectrum · 2025Article
- Investigation and pathogenetic testing of Shewanella spp. positive diarrhea cases in Beijing, China.Scientific reports · 2025Article
- Genomic diversity of mcr-carrying plasmids and the role of type IV secretion systems in IncI2 plasmids conjugation.Communications biology · 2025Article
- VirBR counter-silences HppX3 to promote conjugation of blaNDM-IncX3 plasmids.Nucleic acids research · 2025Article
- Phytochemical Analysis, Antibacterial, and Antitumor Potential ofScientifica · 2025Article
- Membrane association and polar localization of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- T6SS in plant pathogens: unique mechanisms in complex hosts.Infection and immunity · 2024Review
- Comparative analysis of three plasmids fromJAC-antimicrobial resistance · 2024Article
- VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of blaNature communications · 2024Article
- Conjugative type IV secretion systems enable bacterial antagonism that operates independently of plasmid transfer.Communications biology · 2024Article
- The evolutionary genomics of adaptation to stress in wild rhizobium bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structural and functional diversity of type IV secretion systems.Nature reviews. Microbiology · 2024Review
273 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Type IV secretion (T4S) systems are ancestrally related to bacterial conjugation machines. These systems assemble as a translocation channel, and often also as a surface filament or protein adhesin, at the envelopes of Gram-negative and Gram-positive bacteria. These organelles mediate the transfer of DNA and protein substrates to phylogenetically diverse prokaryotic and eukaryotic target cells. Many basic features of T4S are known, including structures of machine subunits, steps of machine assembly, substrates and substrate recognition mechanisms, and cellular consequences of substrate translocation. A recent advancement also has enabled definition of the translocation route for a DNA substrate through a T4S system of a Gram-negative bacterium. This review emphasizes the dynamics of assembly and function of model conjugation systems and the Agrobacterium tumefaciens VirB/D4 T4S system. We also summarize salient features of the increasingly studied effector translocator systems of mammalian pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.