ArticleIn vitro cellular & developmental biology. Animal
Microvascular endothelial cells sustain preadipocyte viability under hypoxic conditions.
Article in In vitro cellular & developmental biology. Animal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Adipose Tissue Engineering Biomaterials: Smart Scaffolds, Vascularization, and Clinical Frontiers.Biomolecules · 2026Review
- Biomimetic Approaches in Clinical Endodontics.Biomimetics (Basel, Switzerland) · 2022Review
- Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?International journal of molecular sciences · 2021Review
- Biomaterials to Mimic and Heal Connective Tissues.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- Autologous fat grafting: Latest insights.Annals of medicine and surgery (2012) · 2019Review
- Post implantation fate of adipogenic induced mesenchymal stem cells on Type I collagen scaffold in a rat model.Journal of materials science. Materials in medicine · 2017Article
- Directing parthenogenetic stem cells differentiate into adipocytes for engineering injectable adipose tissue.Stem cells international · 2014Article
- The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.Diabetologia · 2012Article
- Adipocyte morphometric evaluation and angiogenesis in the omentum transposed to the breast: a preliminary study.Clinics (Sao Paulo, Brazil) · 2011Article
- Stromal vascular progenitors in adult human adipose tissue.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010Article
- Enhanced proliferation of human umbilical vein endothelial cells and differentiation of 3T3-L1 adipocytes in coculture.Tissue engineering. Part A · 2009Article
- Controlled dexamethasone delivery via double-walled microspheres to enhance long-term adipose tissue retention.Journal of tissue engineeringArticle
- Aortic preadipocyte differentiation into adipocytes induced by rosiglitazone in an in vitro model.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity, soft tissue wound healing, adipose tissue engineering, lipomas, and other physiological and pathophysiological conditions necessitate a clear understanding of the interactions between adipocytes and endothelial cells. Adipogenesis and angiogenesis are intimately integrated, despite not being in direct apposition with one another. However, underlying mechanisms have not been elucidated. In this study, the interactions of preadipocytes (PAs) and microvascular endothelial cells are investigated under varying defined O2 conditions, using a coculture system. Results clearly demonstrate that endothelial cells release a soluble factor that sustains PAs viability under hypoxic conditions. Vascular endothelial cell growth factor is not the potential soluble factor (data not shown).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.