ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2005
Selection of eating-disorder phenotypes for linkage analysis.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating.Biological psychiatry · 2017Article
- Targeting Neural Endophenotypes of Eating Disorders with Non-invasive Brain Stimulation.Frontiers in neuroscience · 2016Review
- Genetic association of recovery from eating disorders: the role of GABA receptor SNPs.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- An Association Study of the A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene with Eating Disorders in a Korean Population: A Pilot Study.Psychiatry investigation · 2009Article
- The genetics of anorexia nervosa collaborative study: methods and sample description.The International journal of eating disorders · 2008Article
- Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2005Article
- Posttraumatic stress disorder in anorexia nervosa.Psychosomatic medicineArticle
- Association of candidate genes with phenotypic traits relevant to anorexia nervosa.European eating disorders review : the journal of the Eating Disorders AssociationArticle
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Authors and funding
18 authors at 13 institutions in 5 countries.
Funding
Abstract
Vulnerability to anorexia nervosa (AN) and bulimia nervosa (BN) arise from the interplay of genetic and environmental factors. To explore the genetic contribution, we measured over 100 psychiatric, personality, and temperament phenotypes of individuals with eating disorders from 154 multiplex families accessed through an AN proband (AN cohort) and 244 multiplex families accessed through a BN proband (BN cohort). To select a parsimonious subset of these attributes for linkage analysis, we subjected the variables to a multilayer decision process based on expert evaluation and statistical analysis. Criteria for trait choice included relevance to eating disorders pathology, published evidence for heritability, and results from our data. Based on these criteria, we chose six traits to analyze for linkage. Obsessionality, Age-at-Menarche, and a composite Anxiety measure displayed features of heritable quantitative traits, such as normal distribution and familial correlation, and thus appeared ideal for quantitative trait locus (QTL) linkage analysis. By contrast, some families showed highly concordant and extreme values for three variables-lifetime minimum Body Mass Index (lowest BMI attained during the course of illness), concern over mistakes, and food-related obsessions-whereas others did not. These distributions are consistent with a mixture of populations, and thus the variables were matched with covariate linkage analysis. Linkage results appear in a subsequent report. Our report lays out a systematic roadmap for utilizing a rich set of phenotypes for genetic analyses, including the selection of linkage methods paired to those phenotypes.
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