ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2005
Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 68 citations in OpenAlex.
- Review
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating.Biological psychiatry · 2017Article
- A genome-wide association study of anorexia nervosa.Molecular psychiatry · 2014Article
- Perplexities of treatment resistance in eating disorders.BMC psychiatry · 2013Review
- Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Current status of functional imaging in eating disorders.The International journal of eating disorders · 2012Review
- A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.Molecular psychiatry · 2011Article
- Role of the evolutionarily conserved starvation response in anorexia nervosa.Molecular psychiatry · 2011Review
- Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Impact of broadening definitions of anorexia nervosa on sample characteristics.Journal of psychiatric research · 2011Article
- Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa.Clinical psychology review · 2010Review
- Association study of 182 candidate genes in anorexia nervosa.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Eating disorders: the current status of molecular genetic research.European child & adolescent psychiatry · 2010Review
- The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.International journal of child and adolescent health · 2009Article
- The genetics of anorexia nervosa collaborative study: methods and sample description.The International journal of eating disorders · 2008Article
- Neurobiology of anorexia and bulimia nervosa.Physiology & behavior · 2008Review
- Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.Molecular psychiatry · 2007Article
- Selection of eating-disorder phenotypes for linkage analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2005Article
- Exploring the gene-environment nexus in eating disorders.Journal of psychiatry & neuroscience : JPN · 2005Review
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Authors and funding
18 authors at 13 institutions in 5 countries.
Funding
Abstract
To increase the likelihood of finding genetic variation conferring liability to eating disorders, we measured over 100 attributes thought to be related to liability to eating disorders on affected individuals from multiplex families and two cohorts: one recruited through a proband with anorexia nervosa (AN; AN cohort); the other recruited through a proband with bulimia nervosa (BN; BN cohort). By a multilayer decision process based on expert evaluation and statistical analysis, six traits were selected for linkage analysis (1): obsessionality (OBS), age at menarche (MENAR), and anxiety (ANX) for quantitative trait locus (QTL) linkage analysis; and lifetime minimum body mass index (BMI), concern over mistakes (CM), and food-related obsessions (OBF) for covariate-based linkage analysis. The BN cohort produced the largest linkage signals: for QTL linkage analysis, four suggestive signals: (for MENAR, at 10p13; for ANX, at 1q31.1, 4q35.2, and 8q13.1); for covariate-based linkage analyses, both significant and suggestive linkages (for BMI, one significant [4q21.1] and three suggestive [3p23, 10p13, 5p15.3]; for CM, two significant [16p13.3, 14q21.1] and three suggestive [4p15.33, 8q11.23, 10p11.21]; and for OBF, one significant [14q21.1] and five suggestive [4p16.1, 10p13.1, 8q11.23, 16p13.3, 18p11.31]). Results from the AN cohort were far less compelling: for QTL linkage analysis, two suggestive signals (for OBS at 6q21 and for ANX at 9p21.3); for covariate-based linkage analysis, five suggestive signals (for BMI at 4q13.1, for CM at 11p11.2 and 17q25.1, and for OBF at 17q25.1 and 15q26.2). Overlap between the two cohorts was minimal for substantial linkage signals.
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