ArticlePflugers Archiv : European journal of physiology2006
Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Phosphate: An Anion Controlling Metabolic Functions.Nutrients · 2026Review
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- Tumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases.Calcified tissue international · 2022Review
- Phosphaturic mesenchymal tumors: what an endocrinologist should know.Journal of endocrinological investigation · 2018Review
- Acute Adaption to Oral or Intravenous Phosphate Requires Parathyroid Hormone.Journal of the American Society of Nephrology : JASN · 2017Article
- Tumor-Induced Osteomalacia.Translational endocrinology & metabolism · 2015Article
- The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.Pflugers Archiv : European journal of physiology · 2013Article
- Phosphatonins: new hormones involved in numerous inherited bone disorders.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2011Article
- Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis.Endocrinology · 2011Article
- Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.Pflugers Archiv : European journal of physiology · 2010Article
- Regulation of phosphate transport in proximal tubules.Pflugers Archiv : European journal of physiology · 2009Review
- Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemia.Annals of surgery · 2009Article
- Novel mechanisms in the regulation of phosphorus homeostasis.Physiology (Bethesda, Md.) · 2009Review
- Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis.Laboratory investigation; a journal of technical methods and pathology · 2009Review
- Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.Birth defects research. Part C, Embryo today : reviews · 2008Review
- Biological activity of FGF-23 fragments.Pflugers Archiv : European journal of physiology · 2007Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The phosphatonin, secreted frizzled-related protein-4 (sFRP-4), induces phosphaturia and inhibits 25-hydroxyvitamin D 1alpha-hydroxylase activity normally induced in response to hypophosphatemia. To determine the mechanism by which sFRP-4 alters renal phosphate (P(i)) transport, we examined the effect of sFRP-4 on renal brush border membrane (BBMV) Na(+)-dependent P(i) uptake, and the abundance and localization of the major Na(+)-P(i)-IIa co-transporter in proximal tubules and opossum kidney (OK) cells. Infusion of sFRP-4 increased renal fractional excretion of P(i) and decreased renal beta-catenin concentrations. The increase in renal P(i) excretion with sFRP-4 infusion was associated with a 21.9 +/- 3.4% decrease in BBMV Na(+)-dependent P(i) uptake (P < 0.001) compared with a 39.5 +/- 2.1% inhibition of Na(+)-dependent P(i) transport in renal BBMV induced by PTH (P < 0.001). sFRP-4 infusion was associated with a 30.7 +/- 4.8% decrease in Na(+)-P(i)-IIa co-transporter protein abundance (P < 0.01) assessed by immunoblotting methods compared to a 45.4 +/- 8.8% decrease induced by PTH (P < 0.001). In OK cells, sFRP-4 reduced surface expression of a heterologous Na(+)-P(i)-IIa co-transporter. We conclude that sFRP-4 increases renal P(i) excretion by reducing Na(+)-P(i)-IIa transporter abundance in the brush border of the proximal tubule through enhanced internalization of the protein.
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Registered trials
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