ArticleMammalian genome : official journal of the International Mammalian Genome Society2005
Simultaneous mapping of epistatic QTL in DU6i x DBA/2 mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Quantitative trait loci for resistance to Flavobacterium psychrophilum in rainbow trout: effect of the mode of infection and evidence of epistatic interactions.Genetics, selection, evolution : GSE · 2018Article
- Genetic interactions contribute less than additive effects to quantitative trait variation in yeast.Nature communications · 2015Article
- Mapping epistatic quantitative trait loci.BMC genetics · 2014Article
- Genome-wide linkage analyses identify Hfhl1 and Hfhl3 with frequency-specific effects on the hearing spectrum of NIH Swiss mice.BMC genetics · 2012Article
- Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.Circulation. Cardiovascular genetics · 2012Article
- Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age research.Aging cell · 2012Article
- Dissection of QTL effects for root traits using a chromosome arm-specific mapping population in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Epistasis: obstacle or advantage for mapping complex traits?PloS one · 2010Article
- Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate.BMC genomics · 2010Article
- A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL.BMC genomics · 2009Article
- QTL, additive and epistatic effects for SCN resistance in PI 437654.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both.Physiological genomics · 2009Article
- Genetic influences on growth and body composition in mice: multilocus interactions.International journal of obesity (2005) · 2009Article
- Data and theory point to mainly additive genetic variance for complex traits.PLoS genetics · 2008Review
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have mapped epistatic quantitative trait loci (QTL) in an F2 cross between DU6i x DBA/2 mice. By including these epistatic QTL and their interaction parameters in the genetic model, we were able to increase the genetic variance explained substantially (8.8%-128.3%) for several growth and body composition traits. We used an analysis method based on a simultaneous search for epistatic QTL pairs without assuming that the QTL had any effect individually. We were able to detect several QTL that could not be detected in a search for marginal QTL effects because the epistasis cancelled out the individual effects of the QTL. In total, 23 genomic regions were found to contain QTL affecting one or several of the traits and eight of these QTL did not have significant individual effects. We identified 44 QTL pairs with significant effects on the traits, and, for 28 of the pairs, an epistatic QTL model fit the data significantly better than a model without interactions. The epistatic pairs were classified by the significance of the epistatic parameters in the genetic model, and visual inspection of the two-locus genotype means identified six types of related genotype-phenotype patterns among the pairs. Five of these patterns resembled previously published patterns of QTL interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.