Evidence map›Paper›PMID 16151535›Full record

ArticleJournal of psychiatry & neuroscience : JPN2005

Stressed or stressed out: what is the difference?

Bruce S McEwen

2 registry-linked trialsAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 197 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05019131 nacompletednot on this mapstarted 2021, after this paper: background citation

Addressing Provider Stress and Unconscious Bias to Improve Quality of Maternal Health Care

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2023Enrolled83ConditionsMaternal Health, Mental Health, Healthcare Provider, Adverse OutcomesArmsTraining, Peer support and mentorship, Leadership engagement, Embedded champions
NCT06085105 nacompletednot on this mapstarted 2024, after this paper: background citation

Caring for Providers to Improve Patient Experience (CPIPE) Study: A Cluster Randomized-controlled Trial to Assess the Impact of the CPIPE Intervention on Person-centered Maternity Care

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2026Enrolled6,379ConditionsStress, Psychological, Maternal Health, Healthcare Provider, Adverse OutcomesArmsCPIPE Training, Peer support groups, Mentorship, Leadership engagement, Embedded champions
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  11. Maximal tachycardia and high cardiac strain during night shifts of emergency physicians.International archives of occupational and environmental health · 2017
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  14. Neurobiology of Pet Loss Grief: A Review from a One Health Perspective.Animals : an open access journal from MDPI · 2026
    Review
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  18. Frontiers in psychiatry · 2026
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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bruce S McEwenLaboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA. mcewen@rockefeller.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term "allostasis" has been coined to clarify ambiguities associated with the word "stress". Allostasis refers to the adaptive processes that maintain homeostasis through the production of mediators such as adrenalin, cortisol and other chemical messengers. These mediators of the stress response promote adaptation in the aftermath of acute stress, but they also contribute to allostatic overload, the wear and tear on the body and brain that result from being "stressed out". This conceptual framework has created a need to know how to improve the efficiency of the adaptive response to stressors while minimizing overactivity of the same systems, since such overactivity results in many of the common diseases of modern life. This framework has also helped to demystify the biology of stress by emphasizing the protective as well as the damaging effects of the body's attempts to cope with the challenges known as stressors.

Indexed as

Adaptation, PhysiologicalHomeostasisHumansStress, PsychologicalTerminology as Topic

Identifiers

PMID16151535
PMCPMC1197275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.