ArticleEukaryotic cell2005
Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 148 citations in OpenAlex.
- StudyingPharmaceuticals (Basel, Switzerland) · 2025Review
- A Comprehensive Overview ofJournal of fungi (Basel, Switzerland) · 2025Review
- The Hidden Fortress: A Comprehensive Review of Fungal Biofilms with Emphasis onJournal of fungi (Basel, Switzerland) · 2025Review
- Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during earlyMicrobiology spectrum · 2025Article
- Article
- The Landscape of Gene Expression during Hyperfilamentous Biofilm Development in OralInternational journal of molecular sciences · 2022Article
- Antifungal Effect of Penicillamine Due to the Selective Targeting of L-HomoserineInternational journal of molecular sciences · 2022Article
- Global translational landscape of the Candida albicans morphological transition.G3 (Bethesda, Md.) · 2021Article
- Review
- Article
- Transcriptome Analyses ofG3 (Bethesda, Md.) · 2020Article
- Pseudouridine synthase 7 impacts Candida albicans rRNA processing and morphological plasticity.Yeast (Chichester, England) · 2019Article
- Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.Scientific reports · 2019Article
- Microevolution of the pathogenic yeastsMicrobial cell (Graz, Austria) · 2019Review
- Review
- Article
- Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides.Polish journal of microbiology · 2018Article
- Pseudomonas aeruginosamSphere · 2018Article
- Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms.PloS one · 2018Article
- The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells.Journal of fungi (Basel, Switzerland) · 2017Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The ability to adhere to surfaces and develop as a multicellular community is an adaptation used by most microorganisms to survive in changing environments. Biofilm formation proceeds through distinct developmental phases and impacts not only medicine but also industry and evolution. In organisms such as the opportunistic pathogen Candida albicans, the ability to grow as biofilms is also an important mechanism for persistence, facilitating its growth on different tissues and a broad range of abiotic surfaces used in medical devices. The early stage of C. albicans biofilm is characterized by the adhesion of single cells to the substratum, followed by the formation of an intricate network of hyphae and the beginning of a dense structure. Changes in the transcriptome begin within 30 min of contact with the substrate and include expression of genes related to sulfur metabolism, in particular MET3, and the equivalent gene homologues of the Ribi regulon in Saccharomyces cerevisiae. Some of these changes are initiated early and maintained throughout the process; others are restricted to the earliest stages of biofilm formation. We identify here a potential alternative pathway for cysteine metabolism and the biofilm-associated expression of genes involved in glutathione production in C. albicans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.