ArticleBiophysical journal2005
Effect of temperature on the nanomechanics of lipid bilayers studied by force spectroscopy.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed.
- Uniform Microscale Thermoresponsive Liposomes for Controlled Release Above Body Temperature.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Protein drift-diffusion in membranes with non-equilibrium fluctuations arising from gradients in concentration or temperature.PLoS computational biology · 2025Article
- The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers.The Journal of membrane biology · 2025Article
- Investigation of Cell Damage Induced by Silver Nanoparticles in a Model Cell System.Pharmaceutics · 2025Article
- Structure and thermodynamics of supported lipid membranes on hydrophobic van der Waals surfaces.Soft matter · 2024Article
- Atomic-scale structure of interfacial water on gel and liquid phase lipid membranes.Faraday discussions · 2024Article
- Malaria parasites release vesicle subpopulations with signatures of different destinations.EMBO reports · 2022Article
- Membrane elasticity modulated by cholesterol in model of porcine eye lens-lipid membrane.Experimental eye research · 2022Article
- Formation and Nanoscale Characterization of Asymmetric Supported Lipid Bilayers Containing Raft-Like Domains.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Manipulation of Lipid Membranes with Thermal Stimuli.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Lipid Self-Assemblies under the Atomic Force Microscope.International journal of molecular sciences · 2021Review
- Mechanical properties of the high cholesterol-containing membrane: An AFM study.Biochimica et biophysica acta. Biomembranes · 2021Article
- How arginine derivatives alter the stability of lipid membranes: dissecting the roles of side chains, backbone and termini.European biophysics journal : EBJ · 2021Article
- Unveiling a Hidden Event in Fluorescence Correlative Microscopy by AFM Nanomechanical Analysis.Frontiers in molecular biosciences · 2021Article
- C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes.Scientific reports · 2020Article
- Dynamical Organization of Compositionally Distinct Inner and Outer Membrane Lipids of Mycobacteria.Biophysical journal · 2020Article
- Pathological transitions in myelin membranes driven by environmental and multiple sclerosis conditions.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Hagfish slime exudate stabilization and its effect on slime formation and functionality.Biology open · 2017Article
- Phase behavior of supported lipid bilayers: A systematic study by coarse-grained molecular dynamics simulations.The Journal of chemical physics · 2017Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The effect of temperature on the nanomechanical response of supported lipid bilayers has been studied by force spectroscopy with atomic force microscopy. We have experimentally proved that the force needed to puncture the lipid bilayer (Fy) is temperature dependent. The quantitative measurement of the evolution of Fy with temperature has been related to the structural changes that the surface undergoes as observed through atomic force microscopy images. These studies were carried out with three different phosphatidylcholine bilayers with different main phase transition temperature (TM), namely, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, and 2-dilauroyl-sn-glycero-3-phosphocholine. The solid-like phase shows a much higher Fy than the liquid-like phase, which also exhibits a jump in the force curve. Within the solid-like phase, Fy decreases as temperature is increased and suddenly drops as it approaches TM. Interestingly, a "well" in the Fy versus temperature plot occurs around TM, thus proving an "anomalous mechanical softening" around TM. Such mechanical softening has been predicted by experimental techniques and also by molecular dynamics simulations and interpreted in terms of water ordering around the phospholipid headgroups. Ion binding has been demonstrated to increase Fy, and its influence on both solid and liquid phases has also been discussed.
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