ArticleNucleic acids research2005
Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value.Frontiers in oncology · 2021Article
- Origins of DNA replication.PLoS genetics · 2019Review
- Effect of UV irradiation on Sulfolobus acidocaldarius and involvement of the general transcription factor TFB3 in the early UV response.Nucleic acids research · 2018Article
- Diversity of the DNA replication system in the Archaea domain.Archaea (Vancouver, B.C.) · 2014Review
- Characterization of the replication initiator Orc1/Cdc6 from the Archaeon Picrophilus torridus.Journal of bacteriology · 2014Article
- Mechanisms for initiating cellular DNA replication.Annual review of biochemistry · 2013Review
- Article
- A novel DNA nuclease is stimulated by association with the GINS complex.Nucleic acids research · 2011Article
- Different residues on the surface of the Methanothermobacter thermautotrophicus MCM helicase interact with single- and double-stranded DNA.Archaea (Vancouver, B.C.) · 2010Article
- Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.The Journal of biological chemistry · 2010Article
- Localized melting of duplex DNA by Cdc6/Orc1 at the DNA replication origin in the hyperthermophilic archaeon Pyrococcus furiosus.Extremophiles : life under extreme conditions · 2010Article
- Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by regulating its ATPase activity.Nucleic acids research · 2008Article
- The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase.Journal of bacteriology · 2008Article
- Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.Nucleic acids research · 2008Article
- Characterization of the Cdc6 Homologues from the Euryarchaeon Thermoplasma acidophilum.The open biochemistry journal · 2008Article
- Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1.BMC genetics · 2007Article
- Responses of hyperthermophilic crenarchaea to UV irradiation.Genome biology · 2007Article
- DNA replication in the archaea.Microbiology and molecular biology reviews : MMBR · 2006Review
- DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase.Journal of bacteriology · 2006Article
- Minichromosome maintenance helicase activity is controlled by N- and C-terminal motifs and requires the ATPase domain helix-2 insert.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin recognition complex, Cdc6 and the minichromosome maintenance (MCM) complex play essential roles in the initiation of eukaryotic DNA replication. Homologs of these proteins may play similar roles in archaeal replication initiation. While the interactions among the eukaryotic initiation proteins are well documented, the protein-protein interactions between the archaeal proteins have not yet been determined. Here, an extensive structural and functional analysis of the interactions between the Methanothermobacter thermautotrophicus MCM and the two Cdc6 proteins (Cdc6-1 and -2) identified in the organism is described. The main contact between Cdc6 and MCM occurs via the N-terminal portion of the MCM protein. It was found that Cdc6-MCM interaction, but not Cdc6-DNA binding, plays the predominant role in regulating MCM helicase activity. In addition, the data showed that the interactions with MCM modulate the autophosphorylation of Cdc6-1 and -2. The results also suggest that MCM and DNA may compete for Cdc6-1 protein binding. The implications of these observations for the initiation of archaeal DNA replication are discussed.
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