ArticleProceedings of the National Academy of Sciences of the United States of America2005
Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Hippocampal Non-Theta-Contingent Eyeblink Classical Conditioning: A Model System for Neurobiological Dysfunction.Frontiers in psychiatry · 2016Review
- The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.Behavioral neuroscience · 2015Review
- Pretrial hippocampal θ-state differentiates single-unit response profiles during rabbit trace eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Manipulating motor performance and memory through real-time fMRI neurofeedback.Biological psychology · 2015Article
- Harnessing the power of theta: natural manipulations of cognitive performance during hippocampal theta-contingent eyeblink conditioning.Frontiers in systems neuroscience · 2015Review
- Theta variation and spatiotemporal scaling along the septotemporal axis of the hippocampus.Frontiers in systems neuroscience · 2015Review
- GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.Brain structure & function · 2014Article
- Article
- Serotonergic modulation of hippocampal theta activity in relation to hippocampal information processing.Experimental brain research · 2013Review
- A method for closed-loop presentation of sensory stimuli conditional on the internal brain-state of awake animals.Journal of neuroscience methods · 2013Article
- When the brain is prepared to learn: enhancing human learning using real-time fMRI.NeuroImage · 2012Article
- Learning to learn: theta oscillations predict new learning, which enhances related learning and neurogenesis.PloS one · 2012Article
- Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization.Neurobiology of aging · 2009Article
- Brief novelty exposure facilitates dentate gyrus LTP in aged rats.Hippocampus · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related learning deficits are often attributed to deterioration of hippocampal function. Conversely, a well studied index of hippocampal activity, the rhythm, is known to enhance hippocampal plasticity and accelerate learning rate in young subjects, suggesting that manipulations of activity might be used as a means to counteract impairments related to the aging process. Here, young and older rabbits were given eyeblink conditioning trials either when exhibiting hippocampal (+) or regardless of hippocampal activity (yoked control). Although, as expected, older-yoked control animals showed a learning deficit, the older + group learned as fast as young controls, demonstrating that aging deficits, at least in eyeblink classical conditioning, can be overcome by giving trials during episodes of hippocampal activity. The use of several learning criteria showed that the benefits of hippocampal occur in multiple phases of learning that may depend on different cognitive or motor processes. Whereas there was a benefit of -triggered training in both age groups during the early phase of acquisition, the enhancement persisted in older animals, peaking during later performance. These findings have implications for theories of age-related memory deficits and may contribute to the development of beneficial treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.