Trial reportWorld journal of gastroenterology2005
American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings.
Trial report in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06679725 (Effects of Wild Ginseng Extract on Exercise Performance, Cognitive Function, and Fatigue Recovery Using College Students), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Wild Ginseng Extract on Exercise Performance, Cognitive Function, and Fatigue Recovery Using College Students: a Randomized Cross-Over, Placebo-Controlled, and Double-Blind Study
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.Journal of the International Society of Sports Nutrition · 2021Pooled it
- Efficacy of Ginseng Supplements on Fatigue and Physical Performance: a Meta-analysis.Journal of Korean medical science · 2016Pooled it
- Ginsenosides from American ginseng: chemical and pharmacological diversity.Phytochemistry · 2011Pooled it
- Trial
- Review
- Anti-fatigue effects of Korean Red Ginseng extract in healthy Japanese adults: A randomized, double-blind, placebo-controlled study.Journal of ginseng research · 2025Article
- Herbal paw-sibilities: potential use and challenges ofAnimal frontiers : the review magazine of animal agriculture · 2024Article
- Review
- Unlocking the Antioxidant Potential of White Tea and Osmanthus Flower: A Novel Polyphenol Liquid Preparation and Its Impact on KM Mice and Their Offspring.Foods (Basel, Switzerland) · 2023Article
- Nutritional Compounds to Improve Post-Exercise Recovery.Nutrients · 2022Review
- Neuronal mechanisms of ginseng on antiobesity effects: implication of its synergistic benefits with physical exercise.Journal of exercise rehabilitation · 2021Review
- Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives.European journal of applied physiology · 2020Review
- Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review.Sports medicine - open · 2019Review
- Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage.Food & nutrition research · 2017Article
- Evaluation of anti-fatigue property of the extruded product of cereal grains mixed withJournal of the International Society of Sports Nutrition · 2017Article
- Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice.Molecules (Basel, Switzerland) · 2014Article
- Astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice.Molecules (Basel, Switzerland) · 2014Article
- Deer Antler Extract Improves Fatigue Effect through Altering the Expression of Genes Related to Muscle Strength in Skeletal Muscle of Mice.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- International Society of Sports Nutrition position stand: energy drinks.Journal of the International Society of Sports Nutrition · 2013Article
- Effects of pulse current on endurance exercise and its anti-fatigue properties in the hepatic tissue of trained rats.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether American ginseng (AG, Panax quinquefolium) supplementation was able to improve endurance exercise performance.
methodsThirteen physically active male college students were divided into two groups (AG or placebo) and received supplementation for 4 wk, before the exhaustive running exercise. Treadmill speed was increased to a pace equivalent to 80% VO2max of the subject. A 4-wk washout period followed before the subjects crossed over and received the alternate supplement for the next 4 wk. They then completed a second exhaustive running exercise. The physiological variables that were examined included time to exhaustion and oxygen pulse. Moreover, the plasma creatine kinase (CK) and lactate were measured prior to the exercise, at 15 and 30 min during exercise, immediately after exercise, and 20, 40, 60, and 120 min after exercise.
resultsThe major finding of this investigation was that the production plasma CK during the exercise significantly decreased for group AG than for group P. Secondary physiological finding was that 80% VO2max running was not improved over a 4-wk AG supplementation regimen.
conclusionSupplementation with AG for 4 wk prior to an exhaustive aerobic treadmill running reduced the leakage of CK during exercise, but did not enhance aerobic work capacity. The reduction of plasma CK may be due to the fact that AG is effective for the decrease of skeletal muscle cell membrane damage, induced by exercise during the high-intensity treadmill run.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.