ReviewMicrobiology and molecular biology reviews : MMBR2005
N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.
Review in Microbiology and molecular biology reviews : MMBR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Generation and Characterization of Three Novel Mouse Mutant Strains Susceptible to Audiogenic Seizures.Cells · 2024Article
- Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome.The Journal of physiology · 2024Article
- A Novel ENU-InducedBiology · 2023Article
- A novel ENU-induced Cpox mutation causes microcytic hypochromic anemia in mice.Experimental animals · 2022Article
- A novel mutation in Slc2a4 as a mouse model of fatigue.Genes, brain, and behavior · 2019Article
- Derivation and maintenance of mouse haploid embryonic stem cells.Nature protocols · 2019Article
- Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Properties of genes essential for mouse development.PloS one · 2017Article
- Article
- The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.The Journal of investigative dermatology · 2015Article
- A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment.SpringerPlus · 2015Article
- Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.Journal of lipid research · 2013Article
- Going forward with genetics: recent technological advances and forward genetics in mice.The American journal of pathology · 2013Review
- ENU-induced phenovariance in mice: inferences from 587 mutations.BMC research notes · 2012Article
- New insights into behaviour using mouse ENU mutagenesis.Human molecular genetics · 2012Review
- The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.PloS one · 2011Article
- High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.BMC genetics · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mouse, random mutagenesis with N-ethyl-N-nitrosourea (ENU) has been used since the 1970s in forward mutagenesis screens. However, only in the last decade has ENU mutagenesis been harnessed to generate a myriad of new mouse mutations in large-scale genetic screens and focused, smaller efforts. The development of additional genetic tools, such as balancer chromosomes, refinements in genetic mapping strategies, and evolution of specialized assays, has allowed these screens to achieve new levels of sophistication. The impressive productivity of these screens has led to a deluge of mouse mutants that wait to be harnessed. Here the basic large- and small-scale strategies are described, as are the basics of screen design. Finally, and importantly, this review describes the mechanisms by which such mutants may be accessed now and in the future. Thus, this review should serve both as an overview of the power of forward mutagenesis in the mouse and as a resource for those interested in developing their own screens, adding onto existing efforts, or obtaining specific mouse mutants that have already been generated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.