ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 97 citations in OpenAlex.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- The cerebellum converts input data into a hyper low-resolution granule cell code with spatial dimensions: a hypothesis.Royal Society open science · 2025Article
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
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- Efficient sampling-based Bayesian Active Learning for synaptic characterization.PLoS computational biology · 2023Article
- The Shape of Data: a Theory of the Representation of Information in the Cerebellar Cortex.Cerebellum (London, England) · 2022Article
- How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- Role of NMDAR plasticity in a computational model of synaptic memory.Scientific reports · 2021Article
- Recordings from neuron-HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents.The Journal of general physiology · 2021Article
- Spike Activity Regulates Vesicle Filling at a Glutamatergic Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- NeuroMatic: An Integrated Open-Source Software Toolkit for Acquisition, Analysis and Simulation of Electrophysiological Data.Frontiers in neuroinformatics · 2018Article
- Nucleus accumbens feedforward inhibition circuit promotes cocaine self-administration.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Exploring the significance of morphological diversity for cerebellar granule cell excitability.Scientific reports · 2017Article
- Optimal Degrees of Synaptic Connectivity.Neuron · 2017Article
- Heterosynaptic GABAergic plasticity bidirectionally driven by the activity of pre- and postsynaptic NMDA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The amplitude and shape of EPSC waveforms are thought to be important determinants of information processing and storage in the brain, yet relatively little is known about the origins of EPSC variability or how it affects synaptic signaling. We investigated the stochastic determinants of AMPA receptor-mediated EPSC variability at cerebellar mossy fiber-granule cell (MF-GC) connections by combining multiple-probability fluctuation analysis (MPFA) and deconvolution methods. The properties of MF connections with a single release site and the effects of the rapidly equilibrating competitive antagonist kynurenic acid on EPSCs suggest that receptors are not saturated by glutamate during a quantal event and that quanta sum linearly over a wide range of release probabilities. MPFA revealed an average of five vesicular release sites per MF-GC connection. Our results show that the time course of vesicular release is rapid (decay, tau = 75 micros) and independent of release probability, introducing little jitter in the shape or timing of the quantal component of the EPSC at physiological temperature. Moreover, the peak vesicular release rate per release site after an action potential (AP) (approximately 3 ms(-1)) is substantially higher than previously reported for central synapses. Interaction of amplitude fluctuations arising from quantal release and quantal size with the slower, low variability spillover-mediated current produce substantial variability in EPSC shape. Our simulations of MF-GC transmission suggest that quantal variability and transmitter spillover extend the voltage from which AP threshold can be crossed, improving reliability, and that fast vesicular release allows precise signaling across MF connections with heterogeneous weights.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.