ArticlePflugers Archiv : European journal of physiology1992
Desensitization of acetylcholine receptors in BC3H-1 cells.
Article in Pflugers Archiv : European journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Celebrating 50 Years of Single-Channel Recording with the Patch Clamp.The Journal of membrane biology · 2025Review
- Insights Into the Differential Desensitization ofMolecular pharmacology · 2023Article
- Pathways for nicotinic receptor desensitization.The Journal of general physiology · 2020Article
- Rapsyn facilitates recovery from desensitization in fetal and adult acetylcholine receptors expressed in a muscle cell line.The Journal of physiology · 2019Article
- The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.The Journal of physiology · 2018Review
- Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function.Frontiers in physiology · 2016Review
- Unraveling mechanisms underlying partial agonism in 5-HT3A receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Simulation of the kinetics of neuromuscular block: implications for speed of onset.Anesthesia and analgesia · 2013Article
- Desensitization of neurotransmitter-gated ion channels during high-frequency stimulation: a comparative study of Cys-loop, AMPA and purinergic receptors.The Journal of physiology · 2011Article
- Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states.Journal of molecular biology · 2010Article
- The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.British journal of pharmacology · 2009Article
- Acute alcohol action and desensitization of ligand-gated ion channels.Pharmacological reviews · 2009Review
- Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor.Molecular pharmacology · 2009Article
- The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap.PloS one · 2008Article
- Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer.Nature structural & molecular biology · 2008Article
- Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor.The Journal of general physiology · 2006Article
- Maximum likelihood estimation of ion channel kinetics from macroscopic currents.Biophysical journal · 2005Article
- Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors.The Journal of physiology · 2003Article
- Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We studied desensitization of nicotinic acetylcholine (ACh) receptor channels in the clonal BC3H-1 cell line. We measured the current response to rapid perfusion of outside-out patches with 1 microM to 5 mM ACh, carbamylcholine and suberyldicholine. After binding to the receptors and opening the ion channels, all agonists induce a rapid, concentration-dependent decay of channel activity. The time constant of the current decay ranged from several seconds at low agonist concentrations to about 50 ms at saturating concentrations. The decay rate at saturating concentrations was independent of voltage. The ratio of steady-state to peak current ranged from 0.5 at low agonist concentrations to 0.02 or less at high concentrations. The rate of recovery from desensitization after removal of agonist was also measured. For ACh, the recovery time constant was 320 ms; recovery from desensitization by carbamylcholine was twice as fast. A linear kinetic results. The data are consistent with a cyclic model, although, it is not possible to uniquely determine all of the rate constants in this scheme. The results are compared with competitive binding and single channel studies of desensitization in BC3H-1 cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.