ArticleClinical and diagnostic laboratory immunology2005
Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats.
Article in Clinical and diagnostic laboratory immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02878668 (The Predictor of Infectious Complication After Hepatopancreatobiliary Surgery and Monitoring Indicator of Anti-infectious Therapy), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Predictor of Infectious Complication After Hepatopancreatobiliary Surgery and Monitoring Indicator of Anti-infectious Therapy
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
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- Usefulness of procalcitonin in differentiating Candida and bacterial blood stream infections in critically ill septic patients outside the intensive care unit.Internal and emergency medicine · 2017Article
- Procalcitonin as diagnostic marker of infection in solid tumors patients with fever.Scientific reports · 2016Article
- Variation of Circulating Inflammatory Mediators in Staphylococcus aureus and Escherichia coli Bloodstream Infection.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats.Journal of nutrition and metabolism · 2016Article
- Serum procalcitonin levels distinguish Gram-negative bacterial sepsis from Gram-positive bacterial and fungal sepsis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Uterine Microbiota and Immune Parameters Associated with Fever in Dairy Cows with Metritis.PloS one · 2016Article
- Elevated Serum PCT in Septic Shock With Endotoxemia Is Associated With a Higher Mortality Rate.Medicine · 2015Article
- Evaluation of procalcitonin, C-reactive protein, interleukin-6 & serum amyloid A as diagnostic biomarkers of bacterial infection in febrile patients.The Indian journal of medical research · 2015Article
- Prior infections are associated with increased mortality from subsequent blood-stream infections among patients with hematological malignancies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Immune dysfunction prior to Staphylococcus aureus bacteremia is a determinant of long-term mortality.PloS one · 2014Article
- Deletion of the gene encoding calcitonin and calcitonin gene-related peptide α does not affect the outcome of severe infection in mice.American journal of respiratory cell and molecular biology · 2013Article
- A rat model of central venous catheter to study establishment of long-term bacterial biofilm and related acute and chronic infections.PloS one · 2012Article
- Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay.BMC infectious diseases · 2009Article
- Lipoprotein lipase and hydrofluoric acid deactivate both bacterial lipoproteins and lipoteichoic acids, but platelet-activating factor-acetylhydrolase degrades only lipoteichoic acids.Clinical and vaccine immunology : CVI · 2009Article
- Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria.BMC infectious diseases · 2008Article
- Serum procalcitonin measurement contribution to the early diagnosis of candidemia in critically ill patients.Intensive care medicine · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gram-negative and gram-positive infections have been considered the most important causes of morbidity and mortality in patients with leukopenia following chemotherapy. However, discrimination between bacterial infections and harmless fever episodes is difficult. Because classical inflammatory signs of infection are often absent and fever is frequently the only sign of infection, the aim of this study was to assess the significance of serum interleukin-6 (IL-6), IL-10, macrophage inflammatory protein-2 (MIP-2), procalcitonin (PCT), and C-reactive protein (CRP) patterns in identifying bacterial infections during start of fever in normal and cyclophosphamide-treated (leukopenic) rats following an injection of lipopolysaccharide (LPS) or muramyl dipeptide (MDP) as a model for gram-negative and gram-positive bacterial infections. We found that, compared to normal rats, immunosuppressed animals exhibited significantly higher fevers and lesser production of all mediators, except IL-6, after toxin challenge. Moreover, compared to rats that received MDP, both groups of animals that received an equivalent dose of LPS showed significantly higher fevers and greater increase in serum cytokine levels. Furthermore, in contrast to those in immunocompetent rats, serum levels of IL-6 and MIP-2 were not significantly changed in leukopenic animals after MDP injection. Other serum markers such as PCT and CRP failed to discriminate between bacterial stimuli in both groups of animals. These results suggest that the use of the analyzed serum markers at an early stage of fever could give useful information for the clinician for excluding gram-negative from gram-positive infections.
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