ReviewMolecular biology of the cell2005
Nuclear actin extends, with no contraction in sight.
Review in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 130 citations in OpenAlex.
- New Insights into Cellular Functions of Nuclear Actin.Biology · 2021Review
- Transcriptome Analysis of the Midgut of the Chinese Oak Silkworm Antheraea pernyi Infected with Antheraea pernyi Nucleopolyhedrovirus.PloS one · 2016Article
- β- and γ-Actins in the nucleus of human melanoma A375 cells.Histochemistry and cell biology · 2015Article
- Involvement of the SATB1/F-actin complex in chromatin reorganization during active cell death.International journal of molecular medicine · 2014Article
- Statins as a novel therapeutic strategy in acute lung injury.Pulmonary circulation · 2012Article
- Dynamic interactions between Bombyx mori nucleopolyhedrovirus and its host cells revealed by transcriptome analysis.Journal of virology · 2012Article
- Active maintenance of nuclear actin by importin 9 supports transcription.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance.International journal of cell biology · 2012Article
- Actin-towards a deeper understanding of the relationship between tissue context, cellular function and tumorigenesis.Cancers · 2011Article
- Nuclear mechanics in disease.Annual review of biomedical engineering · 2011Review
- The role of actin and myosin during spermatogenesis.Molecular biology reports · 2011Review
- The nucleus introduced.Cold Spring Harbor perspectives in biology · 2011Review
- Mechanics of the nucleus.Comprehensive Physiology · 2011Review
- Depletion of nuclear actin is a key mediator of quiescence in epithelial cells.Journal of cell science · 2011Article
- Differential sublocalization of actin variants within the nucleus.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Conformational dynamics of actin: effectors and implications for biological function.Cytoskeleton (Hoboken, N.J.) · 2010Review
- Article
- Identification of FBXO25-interacting proteins using an integrated proteomics approach.Proteomics · 2010Article
- Actin-related protein Arp6 influences H2A.Z-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores.PLoS genetics · 2010Article
- Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites.Journal of cell science · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Within the past two years, actin has been implicated in eukaryotic gene transcription by all three classes of RNA polymerase. Moreover, within just the past year, actin has been identified as a constituent of filaments attached to the nuclear pore complexes and extending into the nucleus. This review summarizes these and other very recent advances in the nuclear actin field and emphasizes the key present issues. On the one hand, we are confronted with a body of evidence for a role of actin in gene transcription but with no known structural basis; on the other hand, there is now evidence for polymeric actin--not likely in the classical F-actin conformation--in the nuclear periphery with no known function. In addition, numerous proteins that interact with either G- or F-actin are increasingly being detected in the nucleus, suggesting that both monomeric and oligomeric or polymeric forms of actin are at play and raising the possibility that the equilibrium between them, perhaps differentially regulated at various intranuclear sites, may be a major determinant of nuclear function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.