ArticleNucleic acids research2005
Open reading frames provide a rich pool of potential natural antisense transcripts in fungal genomes.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Genomic determinants for initiation and length of natural antisense transcripts in Entamoeba histolytica.Scientific reports · 2020Article
- Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp.Parasites & vectors · 2018Article
- OverGeneDB: a database of 5' end protein coding overlapping genes in human and mouse genomes.Nucleic acids research · 2018Article
- Article
- Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues.Molecular plant · 2013Review
- Regulated antisense transcription controls expression of cell-type-specific genes in yeast.Molecular and cellular biology · 2011Article
- Genome-wide identification and analysis of small RNAs originated from natural antisense transcripts in Oryza sativa.Genome research · 2009Article
- The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus.Current genetics · 2008Article
- A cytosine methyltransferase homologue is essential for sexual development in Aspergillus nidulans.PloS one · 2008Article
- Birth and death of gene overlaps in vertebrates.BMC evolutionary biology · 2007Article
- Comparative analysis of structured RNAs in S. cerevisiae indicates a multitude of different functions.BMC biology · 2007Article
- Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species.Nucleic acids research · 2006Article
- Prediction of trans-antisense transcripts in Arabidopsis thaliana.Genome biology · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural antisense transcripts are reported from all kingdoms of life and several recent reports of genomewide screens indicate that they are widely distributed. These transcripts seem to be involved in various biological functions and may govern the expression of their respective sense partner. Very little, however, is known about the degree of evolutionary conservation of antisense transcripts. Furthermore, none of the earlier analyses has studied whether antisense relationships are solely dual or involved in more complex relationships. Here we present a systematic screen for cis- and trans-located antisense transcripts based on open reading frames (ORFs) from five fungal species. The relative number of ORFs involved in antisense relationships varies greatly between the five species. In addition, other significant differences are found between the species, such as the mean length of the antisense region. The majority of trans-located antisense transcripts is found to be involved in complex relationships, resulting in highly connected networks. The analysis of the degree of evolutionary conservation of antisense transcripts shows that most antisense transcripts have no ortholog in any other species. An annotation of antisense transcripts based on Gene Ontology directs to common terms and shows that proteins of genes involved in antisense relationships preferentially localize to the nucleus with common functions in the regulation or maintenance of nucleic acids.
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