ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.EMBO reports · 2018Article
- Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.Biochimica et biophysica acta · 2014Article
- LIF-dependent signaling: new pieces in the Lego.Stem cell reviews and reports · 2012Review
- LIF in the regulation of T-cell fate and as a potential therapeutic.Genes and immunity · 2011Review
- A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.Cell cycle (Georgetown, Tex.) · 2010Article
- The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer.Neoplasia (New York, N.Y.) · 2009Article
- Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.Cell cycle (Georgetown, Tex.) · 2009Article
- Viral and cellular MARCH ubiquitin ligases and cancer.Seminars in cancer biology · 2008Review
- The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.Traffic (Copenhagen, Denmark) · 2008Article
- In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3.Transplant international : official journal of the European Society for Organ Transplantation · 2008Article
- Introduction: immunoregulation: harnessing T cell biology for therapeutic benefit.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Article
- Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology to Harness the Tolerogenic and Reparative Properties of LIF.NanobiomedicineReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune self-tolerance is controlled by a subset of T lymphocytes that are regulatory (Treg) and epigenetically programmed to suppress auto-reactive immune effector cells in vivo. By extrapolation, donor-specific transplantation tolerance might be controlled by donor-specific Treg that have acquired the appropriate epigenetic program for tolerance. Although such tolerance has yet to be achieved in man, proof of concept comes from mouse models where regulatory transplantation tolerance can be induced within the complex micro-environment of the spleen or draining lymph node. By studying whole spleen cell populations in a murine model of transplantation tolerance we have incorporated a complexity of environmental factors when looking for specific features that characterize tolerance versus aggression. This approach has revealed unexpected patterns of gene activity in tolerance and most notably that a novel stem cell gene, axotrophin, regulates T lymphocyte responsiveness both in terms of proliferation and in release of leukaemia inhibitory factor (LIF). Since LIF is a regulator of stem cells in addition to being a key neuropoietic cytokine, these preliminary results linking both axotrophin and LIF to transplantation tolerance lead us to propose that regulatory pathways encoded during the epigenetic development of Treg cells are related to pathways that regulate fate determination of stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.