ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
Lipid rafts and regulation of the cytoskeleton during T cell activation.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies.International journal of molecular sciences · 2024Article
- Quantitative Bio-Imaging Tools to Dissect the Interplay of Membrane and Cytoskeletal Actin Dynamics in Immune Cells.Frontiers in immunology · 2020Review
- Influence of omega-3 fatty acids on bovine luteal cell plasma membrane dynamics.Biochimica et biophysica acta. Biomembranes · 2017Article
- Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction.Nutrients · 2017Review
- Omega-3 fatty acids, lipid rafts, and T cell signaling.European journal of pharmacology · 2016Review
- Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains.The British journal of nutrition · 2014Article
- Effects of cholesterol alterations are mediated via G-protein-related pathways in outer hair cells.Pflugers Archiv : European journal of physiology · 2013Article
- Article
- n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.The Biochemical journal · 2012Article
- A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.PloS one · 2009Article
- Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection.Molecular biology of the cell · 2009Article
- A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.Current biology : CB · 2008Article
- Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells.Pflugers Archiv : European journal of physiology · 2008Article
- Organization and function of TRPC channelosomes.Pflugers Archiv : European journal of physiology · 2007Review
- Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1.Journal of virology · 2007Article
- Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells.Molecular immunology · 2007Article
- Synapses: sites of cell recognition, adhesion, and functional specification.Annual review of biochemistry · 2007Review
- Actin polymerization serves as a membrane domain switch in model lipid bilayers.Biophysical journal · 2006Article
- Switching sides: the actin/membrane lipid connection.Biophysical journal · 2006Article
- Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
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1 author.
Funding
Abstract
The ability of polarized cells to initiate and sustain directional responses to extracellular signals is critically dependent on direct communication between spatially organized signalling modules in the membrane and the underlying cytoskeleton. Pioneering work in T cells has shown that the assembly of signalling modules critically depends on the functional compartmentalization of membrane lipids into ordered microdomains or lipid rafts. The significance of rafts in T cell activation lies not only in their ability to recruit the signalling partners that eventually assemble into a mature immunological synapse but also in their ability to regulate actin dynamics and recruit cytoskeletal associated proteins, thereby achieving the structural polarization underlying stability of the synapse-a critical prerequisite for activation to be sustained. Lipid rafts vary quite considerably in size and visualizing the smallest of them in vivo has been challenging. Nonetheless it is now been shown quite convincingly that a surprisingly large proportion-in the order of 50%-of external membrane lipids (chiefly cholesterol and glycosphingolipids) can be dynamically localized in these liquid ordered rafts. Complementary inner leaflet rafts are less well characterized, but contain phosphoinositides as an important functional component that is crucial for regulating the behaviour of the actin cytoskeleton. This paper provides an overview of the interdependency between signalling and cytoskeletal polarization, and in particular considers how regulation of the cytoskeleton plays a crucial role in the consolidation of rafts and their stabilization into the immunological synapse.
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