ArticleJournal of clinical microbiology2005
Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Isolation and characterization of a Rickettsia from the ovary of a Western black-legged tick, Ixodes pacificus.Ticks and tick-borne diseases · 2019Article
- Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Bioorganic & medicinal chemistry · 2017Article
- Molecular Detection of Tick-Borne Pathogen Diversities in Ticks from Livestock and Reptiles along the Shores and Adjacent Islands of Lake Victoria and Lake Baringo, Kenya.Frontiers in veterinary science · 2017Article
- Multispacer Typing (MST) of Spotted Fever Group Rickettsiae Isolated from Humans and Rats in Chengmai County, Hainan Province, China.Tropical medicine and health · 2014Article
- Clinical detection and characterization of bacterial pathogens in the genomics era.Genome medicine · 2014Article
- Multispacer sequence typing relapsing fever Borreliae in Africa.PLoS neglected tropical diseases · 2012Article
- Evidence of a louse-borne outbreak involving typhus in Douai, 1710-1712 during the war of Spanish succession.PloS one · 2010Article
- Genotyping of human lice suggests multiple emergencies of body lice from local head louse populations.PLoS neglected tropical diseases · 2010Article
- Genotyping Rickettsia prowazekii isolates.Emerging infectious diseases · 2008Article
- Article
- Rapid comparative genomic analysis for clinical microbiology: the Francisella tularensis paradigm.Genome research · 2008Article
- Molecular typing of isolates of Rickettsia rickettsii by use of DNA sequencing of variable intergenic regions.Journal of clinical microbiology · 2007Article
- Identification of rickettsial isolates at the species level using multi-spacer typing.BMC microbiology · 2007Article
- Multispacer typing to study the genotypic distribution of Bartonella henselae populations.Journal of clinical microbiology · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, there is no tool for typing Rickettsia prowazekii, the causative agent of epidemic typhus, currently considered a potential bioterrorism agent, at the strain level. To test if the multispacer typing (MST) method could differentiate strains of R. prowazekii, we amplified and sequenced the 25 most variable intergenic spacers between the R. prowazekii and R. conorii genomes in five strains and 10 body louse amplicons of R. prowazekii from various geographic origins. Two intergenic spacers, i.e., rpmE/tRNA(fMet) and serS/virB4, were variable among tested R. prowazekii isolates and allowed identification of three and two genotypes, respectively. When the genotypes obtained from the two spacers were combined, we identified four different genotypes. MST demonstrated that several R. prowazekii strains circulated in human body lice during an outbreak of epidemic typhus in Burundi. This may help to discriminate between natural and intentional outbreaks. Our study supports the usefulness of MST as a versatile method for rickettsial strain genotyping.
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