ArticleBiomaterials2006
Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves.
Article in Biomaterials, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Pooled it
- Human acellular dermal matrix versus Integra® for single-stage oncologic scalp reconstruction: A multicentre cohort study.JPRAS open · 2026Article
- A preclinical overall evaluation of a novel biomimetic collagen membrane for guided tissue regeneration.Journal of dental sciences · 2026Article
- Biomimetic bilayer hydrogel coating with antithrombotic and anticalcification properties for cardiovascular tissue engineering application.Regenerative biomaterials · 2026Article
- Advances in xenogeneic donor decellularized organs: A review on studies with sheep and porcine-derived heart valves.Bioengineering & translational medicine · 2024Review
- Biomimetic proteoglycans as a tool to engineer the structure and mechanics of porcine bioprosthetic heart valves.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation.Biomimetics (Basel, Switzerland) · 2023Article
- The Sea CucumberJournal of natural products · 2023Article
- Long-term histological effects of high-dose prednisolone administration on the mitral valve in normal Beagle dogs.Open veterinary journal · 2023Article
- Whole-Heart Tissue Engineering and Cardiac Patches: Challenges and Promises.Bioengineering (Basel, Switzerland) · 2023Review
- Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure.Journal of the American Heart Association · 2023Article
- Early and midterm outcomes of a bentall operation using an all-biological valved BioConduit™.Journal of cardiothoracic surgery · 2022Article
- Novel technique of development of human derived acellular dermal matrix.Cell and tissue banking · 2022Article
- The hybrid crosslinking method improved the stability and anti-calcification properties of the bioprosthetic heart valves.Frontiers in bioengineering and biotechnology · 2022Article
- Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection.The Journal of biological chemistry · 2021Article
- Evaluation of decellularization protocols for production of porcine small intestine submucosa for use in abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Degeneration of Bioprosthetic Heart Valves: Update 2020.Journal of the American Heart Association · 2020Review
- Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing.Biomaterials · 2019Review
- An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets.Journal of the Royal Society, Interface · 2019Article
- Multi-laminate annulus fibrosus repair scaffold with an interlamellar matrix enhances impact resistance, prevents herniation and assists in restoring spinal kinematics.Journal of the mechanical behavior of biomedical materials · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Glycosaminoglycans (GAGs) are important structural and functional components in native aortic heart valves and in glutaraldehyde (Glut)-fixed bioprosthetic heart valves (BHVs). However, very little is known about the fate of GAGs within the extracellular matrix of BHVs and their contribution to BHV longevity. BHVs used in heart valve replacement surgery have limited durability due to mechanical failure and pathologic calcification. In the present study we bring evidence for the dramatic loss of GAGs from within the BHV cusp structure during storage in saline and both short- and long-term Glut fixation. In order to gain insight into role of GAGs, we compared properties of fresh and Glut-fixed porcine heart valve cusps before and after complete GAG removal. GAG removal resulted in significant morphological and functional tissue alterations, including decreases in cuspal thickness, reduction of water content and diminution of rehydration capacity. By virtue of this diminished hydration, loss of GAGs also greatly increased the "with-curvature" flexural rigidity of cuspal tissue. However, removal of GAGs did not alter calcification potential of BHV cups when implanted in the rat subdermal model. Controlling the extent of pre-implantation GAG degradation in BHVs and development of improved GAG crosslinking techniques are expected to improve the mechanical durability of future cardiovascular bioprostheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.