ArticleBMJ (Clinical research ed.)2005
Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial.
Article in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 8 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 8 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth.The Cochrane database of systematic reviews · 2022Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2022Pooled it
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2020Pooled it
- Transplacental versus direct fetal corticosteroid treatment for accelerating fetal lung maturation where there is a risk of preterm birth.The Cochrane database of systematic reviews · 2018Pooled it
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2017Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2015Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2011Pooled it
- Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2008Pooled it
- Reproductive outcomes after antenatal corticosteroids: Secondary analysis of 50-year follow-up of the Auckland steroid randomized trial.Acta obstetricia et gynecologica Scandinavica · 2024Trial
- General health and social outcomes 50 years after exposure to antenatal betamethasone: follow-up of a randomised controlled trial.BMC medicine · 2024Trial
- Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial).Archives of disease in childhood. Fetal and neonatal edition · 2013Trial
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
- Neurodevelopmental outcomes in children and adults associated with antenatal corticosteroid exposure: a narrative review.European journal of pediatrics · 2025Review
- Multiple Sclerosis Relapse Treatment During Pregnancy and Offspring Functional and Structural Neurodevelopment: A Cross-Sectional Study.Neurology · 2025Observational
- Early preterm antenatal corticosteroids and neonatal outcomes for twin pregnancies: a propensity score-weighted cohort study.BMC pregnancy and childbirth · 2025Article
- Article
- A comparison of short- and long-term prognoses between cases with and without antenatal corticosteroid administration in late preterm delivery: a nationwide population-based study.BMC pregnancy and childbirth · 2025Observational
- Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids.JAMA network open · 2025Article
- What is the evidence? Updates in the use of antenatal corticosteroids for patients at risk of preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2024Review
- Antenatal corticosteroids in Singapore: a clinical and scientific assessment.Singapore medical journal · 2024Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine if antenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome alters psychological functioning and health related quality of life in adulthood.
designFollow-up of the first and largest double blind, placebo controlled, randomised trial of a single course of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome.
settingTertiary obstetric hospital in Auckland, New Zealand.
participants192 adult offspring, mean age 31 years, of mothers who took part in a randomised controlled trial of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome (87 exposed to betamethasone and 105 exposed to placebo).
interventionsMothers received two doses of betamethasone or placebo 24 hours apart.
main outcome measuresCognitive functioning assessed with Wechsler abbreviated scale of intelligence; working memory and attention assessed with Benton visual retention test, paced auditory serial addition test, and Brown attention deficit disorder scale; psychiatric morbidity assessed with Beck depression inventory II, state-trait anxiety inventory, and schizotypy traits questionnaire; handedness assessed with Edinburgh handedness inventory; health related quality of life assessed with short form 36 health survey.
resultsNo differences were found between groups exposed to betamethasone and placebo in cognitive functioning, working memory and attention, psychiatric morbidity, handedness, or health related quality of life.
conclusionsPrenatal exposure to a single course of betamethasone does not alter cognitive functioning, working memory and attention, psychiatric morbidity, handedness, or health related quality of life in adulthood. Obstetricians should continue to use a single course of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome.
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Registered trials
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