ArticleGenetics2005
Mechanisms of genetic exchange within the chromosomal inversions of Drosophila pseudoobscura.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Article
- Genome-wide diversity of chromosomal inversions and their disease relationships.bioRxiv : the preprint server for biology · 2025Article
- Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (Ecology and evolution · 2025Article
- The recombination landscape of introgression in yeast.PLoS genetics · 2025Article
- Incomplete recombination suppression fuels extensive haplotype diversity in a butterfly colour pattern supergene.PLoS biology · 2025Article
- Chromosomal inversions and their impact on insect evolution.Current opinion in insect science · 2024Review
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- The recombination landscape of introgression in yeast.bioRxiv : the preprint server for biology · 2024Article
- Supergene origin and maintenance in Atlantic cod.Nature ecology & evolution · 2022Article
- Adaptation of Drosophila subobscura chromosomal inversions to climatic variables: the Balkan natural population of Avala.Genetica · 2021Article
- The Effect of Neutral Recombination Variation on Genome Scans for Selection.G3 (Bethesda, Md.) · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- Pervasive gene conversion in chromosomal inversion heterozygotes.Molecular ecology · 2019Article
- Patterns of geographic variation of thermal adapted candidate genes in Drosophila subobscura sex chromosome arrangements.BMC evolutionary biology · 2018Article
- Extensive exchange of transposable elements in theMobile DNA · 2018Article
- Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of Drosophila subobscura.Scientific reports · 2016Article
- The genomics of ecological vicariance in threespine stickleback fish.Nature communications · 2015Article
- Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2014Article
- Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster.Molecular ecology · 2014Article
- Molecular population genetics of inversion breakpoint regions in Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used the inversion system of Drosophila pseudoobscura to investigate how genetic flux occurs among the gene arrangements. The patterns of nucleotide polymorphism at seven loci were used to infer gene conversion events between pairs of different gene arrangements. We estimate that the average gene conversion tract length is 205 bp and that the average conversion rate is 3.4 x 10(-6), which is 2 orders of magnitude greater than the mutation rate. We did not detect gene conversion events between all combinations of gene arrangements even though there was sufficient nucleotide variation for detection and sufficient opportunity for exchanges to occur. Genetic flux across the inverted chromosome resulted in higher levels of differentiation within 0.1 Mb of inversion breakpoints, but a slightly lower level of differentiation in central inverted regions. No gene conversion events were detected within 17 kb of an inversion breakpoint suggesting that the formation of double-strand breaks is reduced near rearrangement breakpoints in heterozygotes. At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified.
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