ArticleGenetics2005
Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- A conserved STRIPAK complex is required for autophagy in muscle tissue.Molecular biology of the cell · 2023Article
- Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.Aging cell · 2021Article
- The Divergent Roles of the Rice bcl-2 Associated Athanogene (BAG) Genes in Plant Development and Environmental Responses.Plants (Basel, Switzerland) · 2021Article
- Genomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations.Molecular biology and evolution · 2020Article
- Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover.PLoS genetics · 2020Article
- Transcriptomic signatures of cold adaptation and heat stress in the winter ant (Prenolepis imparis).PloS one · 2020Article
- Functional Characterization of the Group I Alphabaculovirus Specific Gene ac73.Virologica Sinica · 2019Article
- Article
- Getting folded: chaperone proteins in muscle development, maintenance and disease.Anatomical record (Hoboken, N.J. : 2007) · 2014Review
- Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.Journal of molecular medicine (Berlin, Germany) · 2011Review
- BAG3: a multifaceted protein that regulates major cell pathways.Cell death & disease · 2011Review
- Article
- Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.The Journal of biological chemistry · 2010Article
- IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a developmental, genetic, and molecular analysis of the sole Drosophila member of the BAG family of genes, which is implicated in stress response and survival in mammalian cells. We show that the gene, termed starvin (stv), is expressed in a highly tissue-specific manner, accumulating primarily in tendon cells following germ-band retraction and later in somatic muscles and the esophagus during embryonic stage 15. We show that stv expression falls within known tendon and muscle cell transcriptional regulatory cascades, being downstream of stripe, but not of another tendon transcriptional regulator, delilah, and downstream of the muscle regulator, mef-2. We generated a series of stv alleles and, surprisingly, given the muscle and tendon-specific embryonic expression of stv, found that the gross morphology and function of somatic muscles is normal in stv mutants. Nonetheless, stv mutant larvae exhibit a striking and fully penetrant mutant phenotype of failure to grow after hatching and a severely impaired ability to take up food. Our study provides the first report of an essential, developmentally regulated BAG-family gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.