ArticleGenetics2005
The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Loci Contributing to Boric Acid Toxicity in Two Reference Populations ofG3 (Bethesda, Md.) · 2017Article
- Notch Target Gene E(spl)mδ Is a Mediator of Methylmercury-Induced Myotoxicity inFrontiers in genetics · 2017Article
- Gene expression variation in Drosophila melanogaster due to rare transposable element insertion alleles of large effect.Genetics · 2015Article
- Marker-based estimation of genetic parameters in genomics.PloS one · 2014Article
- Abundance and distribution of transposable elements in two Drosophila QTL mapping resources.Molecular biology and evolution · 2013Article
- Association mapping and the genomic consequences of selection in sunflower.PLoS genetics · 2013Article
- A test for selection employing quantitative trait locus and mutation accumulation data.Genetics · 2012Article
- The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae).BMC evolutionary biology · 2011Article
- The struggle for life of the genome's selfish architects.Biology direct · 2011Review
- Genomic differentiation between temperate and tropical Australian populations of Drosophila melanogaster.Genetics · 2011Article
- Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex.Genome research · 2010Article
- Mating-system variation, demographic history and patterns of nucleotide diversity in the Tristylous plant Eichhornia paniculata.Genetics · 2010Article
- Genetics. Life after GWA studies.Science (New York, N.Y.) · 2009Article
- Experimental evolution reveals natural selection on standing genetic variation.Nature genetics · 2009Article
- An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Revealing the architecture of gene regulation: the promise of eQTL studies.Trends in genetics : TIG · 2008Review
- High DNA sequence diversity in pericentromeric genes of the plant Arabidopsis lyrata.Genetics · 2008Article
- Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster.Genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The Enhancer of split complex [E(spl)-C] in Drosophila encompasses a variety of functional elements controlling bristle patterning and on the basis of prior work is a strong candidate for harboring alleles having subtle effects on bristle number variation. Here we extend earlier studies identifying associations between complex phenotypes and polymorphisms segregating among inbred laboratory lines of Drosophila and test the influence of E(spl)-C on bristle number variation in a natural cohort. We describe results from an association mapping study using 203 polymorphisms spread throughout the E(spl)-C genotyped in 2000 wild-caught Drosophila melanogaster. Despite power to detect associations accounting for as little as 2% of segregating variation for bristle number, and saturating the region with single-nucleotide polymorphisms (SNPs), we identified no single SNP marker showing a significant (additive over loci) effect after correcting for multiple tests. Using a newly developed test we conservatively identify six regions of the E(spl)-C in which the insertion of transposable elements as a class contributes to variation in bristle number, apparently in a sex- or trait-limited fashion. Finally, we carry out all possible 20,503 two-way tests for epistasis and identify a slight excess of marginally significant interactions, although none survive multiple-testing correction. It may not be straightforward to extend the results of laboratory-based association studies to natural populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.