ArticleGenetics2005
Signatures of reproductive isolation in patterns of single nucleotide diversity across inbred strains of mice.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress.Nature communications · 2025Article
- Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone.American journal of biological anthropology · 2023Article
- Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations.Molecular biology and evolution · 2021Article
- Article
- Analysis of recombination QTLs, segregation distortion, and epistasis for fitness in maize multiple populations using ultra-high-density markers.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Genomic heterozygosity and hybrid breakdown in cotton (Gossypium): different traits, different effects.BMC genetics · 2016Article
- The Mosaic Ancestry of the Drosophila Genetic Reference Panel and the D. melanogaster Reference Genome Reveals a Network of Epistatic Fitness Interactions.Molecular biology and evolution · 2015Article
- Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models.Molecular biology and evolution · 2015Article
- Reproductive isolation of hybrid populations driven by genetic incompatibilities.PLoS genetics · 2015Article
- High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species.eLife · 2014Article
- Sequencing, assembling, and correcting draft genomes using recombinant populations.G3 (Bethesda, Md.) · 2014Article
- Article
- Genetic dissection of a key reproductive barrier between nascent species of house mice.Genetics · 2011Article
- Prevalence of segregation distortion in diploid alfalfa and its implications for genetics and breeding applications.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- A complex genetic basis to X-linked hybrid male sterility between two species of house mice.Genetics · 2008Article
- Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus).Heredity · 2008Article
- An imputed genotype resource for the laboratory mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men.PloS one · 2008Article
- Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice.Evolution; international journal of organic evolution · 2008Article
- Genome-wide patterns of gene flow across a house mouse hybrid zone.Genome research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reproductive isolation is often caused by the disruption of genic interactions that evolve in geographically separate populations. Identifying the genomic regions and genes involved in these interactions, known as "Dobzhansky-Muller incompatibilities," can be challenging but is facilitated by the wealth of genetic markers now available in model systems. In recent years, the complete genome sequence and thousands of single nucleotide polymorphisms (SNPs) from laboratory mice, which are largely genetic hybrids between Mus musculus and M. domesticus, have become available. Here, we use these resources to locate genomic regions that may underlie reproductive isolation between these two species. Using genotypes from 332 SNPs that differ between wild-derived strains of M. musculus and M. domesticus, we identified several physically unlinked SNP pairs that show exceptional gametic disequilibrium across the lab strains. Conspecific alleles were associated in a disproportionate number of these cases, consistent with the action of natural selection against hybrid gene combinations. As predicted by the Dobzhansky-Muller model, this bias was differentially attributable to locus pairs for which one hybrid genotype was missing. We assembled a list of potential Dobzhansky-Muller incompatibilities from locus pairs that showed extreme associations (only three gametic types) among conspecific alleles. Two SNPs in this list map near known hybrid sterility loci on chromosome 17 and the X chromosome, allowing us to nominate partners for disrupted interactions involving these genomic regions for the first time. Together, these results indicate that patterns produced by speciation between M. musculus and M. domesticus are visible in the genomes of lab strains of mice, underscoring the potential of these genetic model organisms for addressing general questions in evolutionary biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.