ArticleGenetics2005
Natural and synthetic alleles provide complementary insights into the nature of selection acting on the Men polymorphism of Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- SREBP modulates the NADPNature communications · 2023Article
- Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.Genetics · 2023Article
- A Tale of Two Transcriptomic Responses in Agricultural Pests via Host Defenses and Viral Replication.International journal of molecular sciences · 2021Article
- Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.PloS one · 2016Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Transvection-based gene regulation in Drosophila is a complex and plastic trait.G3 (Bethesda, Md.) · 2014Article
- A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- Interactions of NADP-reducing enzymes across varying environmental conditions: a model of biological complexity.G3 (Bethesda, Md.) · 2012Article
- Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster.Genetics · 2011Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- A model of oxidative stress management: moderation of carbohydrate metabolizing enzymes in SOD1-null Drosophila melanogaster.PloS one · 2011Article
- Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.Genetics · 2009Article
- Article
- Gene expression variation in African and European populations of Drosophila melanogaster.Genome biology · 2008Article
- Flux control and excess capacity in the enzymes of glycolysis and their relationship to flight metabolism in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Triglyceride pools, flight and activity variation at the Gpdh locus in Drosophila melanogaster.Genetics · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Two malic enzyme alleles, Men(113A) and Men(113G), occur at approximately equal frequency in North American populations of Drosophila melanogaster, while only Men(113A) occurs in African populations. We investigated the population genetics, biochemical characteristics, and selective potential of these alleles. Comparable levels of nucleotide polymorphism in both alleles suggest that the Men(113G) allele is not recently derived, but we find no evidence in the DNA sequence data for selection maintaining the polymorphism. Interestingly, the alleles differ in both V(max) and K(m) for the substrate malate. Triglyceride concentration and isocitrate dehydrogenase (IDH) and glucose-6-phosphate dehydrogenase (G6PD) activities are negatively correlated with the in vivo activities of the Men alleles. We examined the causality of the observed correlations using P-element excision-derived knockout alleles of the Men gene and found significant changes in the maximum activities of both IDH and G6PD, but not in triglyceride concentration, suggesting compensatory interactions between MEN, IDH, and G6PD. Additionally, we found significantly higher than expected levels of MEN activity in knockout heterozygotes, which we attribute to transvection effects. The distinct differences in biochemistry and physiology between the naturally occurring alleles and between the engineered alleles suggest the potential for selection on the Men locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.