ArticleBMC medical genetics2005
No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study.
Article in BMC medical genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- ADHD and the DRD4 exon III 7-repeat polymorphism: an international meta-analysis.Social cognitive and affective neuroscience · 2010Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Learning and Memory Impairments With Attention-Deficit/Hyperactivity Disorder.Physiological research · 2024Review
- Molecular Evaluation of Ex3 VNTR Polymorphism of the DRD4 Gene in Patients With Autism Spectrum Disorder.Iranian journal of child neurology · 2022Article
- Exploring characteristic features of attention-deficit/hyperactivity disorder: findings from multi-modal MRI and candidate genetic data.Brain imaging and behavior · 2020Article
- DRD4 Gene Polymorphisms as a Risk Factor for Children with Attention Deficit Hyperactivity Disorder in Iranian Population.International scholarly research notices · 2017Article
- Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder.PloS one · 2017Article
- Polymorphism in variable number of tandem repeats of dopamine d4 gene is a genetic risk factor in attention deficit hyperactive egyptian children: pilot study.Biomarker insights · 2015Article
- Advances in molecular genetic studies of attention deficit hyperactivity disorder in China.Shanghai archives of psychiatry · 2014Review
- Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males.BMC research notes · 2013Article
- Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian probands.BioMed research international · 2013Article
- Molecular genetics of attention deficit hyperactivity disorder.The Psychiatric clinics of North America · 2010Review
- The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.Behavioral and brain functions : BBF · 2008Article
- The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.Molecular psychiatry · 2006Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAttention Deficit Hyperactivity Disorder (ADHD) is a prevalent and highly heritable childhood disorder. The dopamine D4 receptor (DRD4) gene has shown a genetic association with ADHD in Caucasian populations with meta-analysis indicating a small but significant effect across datasets. It remains uncertain whether this association can be generalised to non-Caucasian ethnic groups. Here we investigate two markers within the DRD4 gene in a Taiwanese population, the exon 3 variable number tandem repeat (VNTR) and a 5' 120 base-pair duplication.
methodsWithin-family transmission disequilibrium tests of association of the 5' 120 base-pair duplication, and exon 3 VNTR in a Taiwanese population.
resultsNo evidence of association of ADHD with either polymorphism in this population was observed.
conclusionThe DRD4 gene markers investigated were not found to be associated with ADHD in this Taiwanese sample. Further work in Taiwanese and other Asian populations will therefore be required to establish whether the reports of association of DRD4 genetic variants in Caucasian samples can be generalised to Asian populations.
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