ArticlePflugers Archiv : European journal of physiology2005
Expression of androgen receptor and androgen regulation of NDRG2 in the rat renal collecting duct.
Article in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Sex-Related Expression of Klotho in Rat Kidneys: Species Differences Between Rats and Mice.International journal of molecular sciences · 2026Article
- Sex-Specific Differences in Kidney Function and Blood Pressure Regulation.International journal of molecular sciences · 2024Review
- Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens.Cancers · 2021Article
- Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases.Cellular and molecular life sciences : CMLS · 2020Review
- Sex differences in redox homeostasis in renal disease.Redox biology · 2020Review
- Long-Lasting Androgen-Induced Cardiometabolic Effects in Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2018Article
- N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma.Diagnostic pathology · 2017Article
- Abundant NDRG2 Expression Is Associated with Aggressiveness and Unfavorable Patients' Outcome in Basal-Like Breast Cancer.PloS one · 2016Article
- NDRG2 acts as a negative regulator downstream of androgen receptor and inhibits the growth of androgen-dependent and castration-resistant prostate cancer.Cancer biology & therapy · 2015Article
- N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma.Breast cancer research : BCR · 2014Article
- Testosterone enhances tubuloglomerular feedback by increasing superoxide production in the macula densa.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- The vasodilatory effect of testosterone on renal afferent arterioles.Gender medicine · 2012Article
- N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPase.The Journal of biological chemistry · 2011Article
- Oral contraceptive progestins and angiotensin-dependent control of the renal circulation in humans.Journal of human hypertension · 2009Article
- NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors.The Journal of physiology · 2009Article
- Testosterone influences renal electrolyte excretion in SHR/y and WKY males.BMC physiology · 2008Article
- Gender differences in kidney function.Pflugers Archiv : European journal of physiology · 2007Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgens are known to regulate gene expression in the renal proximal tubule. Whether the distal parts of the nephron, in particular the cortical collecting duct (CCD), where sodium reabsorption is controlled tightly by aldosterone, are also targets for these hormones is unknown. Real-time PCR on rat isolated renal tubules showed that androgen receptor mRNA is not only, as expected, expressed in the proximal tubule, but also in the CCD. We examined the effects of adrenalectomy (ADX) plus castration and in-vivo administration of the active metabolite of testosterone, dihydrotestosterone (DHT), on the intrarenal expression of N-myc downstream regulated gene 2 (NDRG2), an early aldosterone-induced gene located specifically in the CCD. NDRG2 belongs to a newly identified family of differentiation-related genes; although the function of these genes remains elusive, regulation of NDRG1 by androgens has been suggested. Castration plus ADX increased NDRG2 expression (RNase protection assay) significantly in the whole kidney, and a single i.p. injection of DHT caused a significant decrease in NDRG2 expression 4 h afterwards (up to 24 h). Furthermore, real-time PCR on microdissected tubules revealed that the decrease in NDRG2 expression caused by DHT is restricted to the CCD. Thus, aldosterone and androgens have opposite effects on NDRG2 expression in the renal CCD. These results are the first demonstration of androgen-dependent gene regulation in the rat renal CCD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.