ArticleEMBO reports2005
SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification.
Article in EMBO reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule.Computational and structural biotechnology journal · 2022Review
- Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.Scientific reports · 2016Article
- Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.American journal of translational research · 2014Review
- SUMO: a (oxidative) stressed protein.Neuromolecular medicine · 2013Review
- SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.American journal of physiology. Endocrinology and metabolism · 2012Article
- Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury.PloS one · 2011Article
- SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy.Nucleic acids research · 2008Article
- Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5.The Journal of biological chemistry · 2007Article
- Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts.Molecular and cellular biology · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined whether small ubiquitin-related modifier-1 (SUMO-1) regulates apoptosis signal-regulating kinase 1 (ASK 1). ASK 1 interacted with SUMO-1 in vitro as well as in BOSC 23 cells. Endogenous ASK 1-SUMO-1 interaction was disrupted following H(2)O(2) signal. SUMO-1 overexpression suppressed the self-oligomerization, kinase activity and apoptotic potential of ASK 1, whereas SUMO-1 depletion potentiated such activities. SUMO-1(Delta C 6), a sumoylation-incompetent mutant lacking carboxy-terminal six amino acids, suppressed AS 1 activation, implying that the suppressive effect of SUMO-1 on ASK 1 is independent of sumoylation. ASK 1(3M), an ASK 1 mutant in which all three lysines in the psiKXE motif were substituted with alanines, still retained the kinase activity and activated the Jun amino-terminal kinase pathway. However, SUMO-1 failed to interact with ASK 1(3M) and to suppress ASK 1(3M) activation, indicating that the three lysines are important for regulation by SUMO-1. This study shows that SUMO-1 exerts a negative regulatory effect on ASK 1 activation through physical interaction and not through covalent modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.