Trial reportBMJ (Clinical research ed.)2005
A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness.
Trial report in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 150 papers, 20 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis
Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings
PEGASUS - Improving Treatment for Patients With Emotionally Unstable Personality Disorder
Who cites it
150 citing papers in PubMed, 20 syntheses or guidelines pooled it, 571 citations in OpenAlex.
- Cognitive behavioural therapy added to standard care for first-episode and recent-onset psychosis.The Cochrane database of systematic reviews · 2024Pooled it
- Measures of Social and Occupational Function in Early Psychosis: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2024Pooled it
- Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Pooled it
- Humour-based interventions for people with schizophrenia.The Cochrane database of systematic reviews · 2021Pooled it
- Specialised early intervention teams (extended time) for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020Pooled it
- Effectiveness of Family Intervention for Preventing Relapse in First-Episode Psychosis Until 24 Months of Follow-up: A Systematic Review With Meta-analysis of Randomized Controlled Trials.Schizophrenia bulletin · 2020Pooled it
- Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019Pooled it
- Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression.JAMA psychiatry · 2018Pooled it
- Intensive case management for severe mental illness.The Cochrane database of systematic reviews · 2017Pooled it
- A Systematic Review of the Effect of Early Interventions for Psychosis on the Usage of Inpatient Services.Schizophrenia bulletin · 2015Pooled it
- Social skills programmes for schizophrenia.The Cochrane database of systematic reviews · 2015Pooled it
- The role of untreated psychosis in neurodegeneration: a review of hypothesized mechanisms of neurotoxicity in first-episode psychosis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Pooled it
- Training to recognise the early signs of recurrence in schizophrenia.The Cochrane database of systematic reviews · 2013Pooled it
- Collaboration between local health and local government agencies for health improvement.The Cochrane database of systematic reviews · 2012Pooled it
- Antipsychotic medication for early episode schizophrenia.The Cochrane database of systematic reviews · 2011Pooled it
- Early intervention for psychosis.The Cochrane database of systematic reviews · 2011Pooled it
- Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis.Schizophrenia bulletin · 2011Pooled it
- Early intervention services, cognitive-behavioural therapy and family intervention in early psychosis: systematic review.The British journal of psychiatry : the journal of mental science · 2010Pooled it
- Intensive case management for severe mental illness.The Cochrane database of systematic reviews · 2010Pooled it
90 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effects of integrated treatment for patients with a first episode of psychotic illness.
designRandomised clinical trial.
settingCopenhagen Hospital Corporation and Psychiatric Hospital Aarhus, Denmark.
participants547 patients with first episode of schizophrenia spectrum disorder.
interventionsIntegrated treatment and standard treatment. The integrated treatment lasted for two years and consisted of assertive community treatment with programmes for family involvement and social skills training. Standard treatment offered contact with a community mental health centre.
main outcome measuresPsychotic and negative symptoms (each scored from 0 to a maximum of 5) at one and two years' follow-up.
resultsAt one year's follow-up, psychotic symptoms changed favourably to a mean of 1.09 (standard deviation 1.27) with an estimated mean difference between groups of -0.31 (95% confidence interval -0.55 to -0.07, P = 0.02) in favour of integrated treatment. Negative symptoms changed favourably with an estimated difference between groups of -0.36 (-0.54 to -0.17, P < 0.001) in favour of integrated treatment. At two years' follow-up the estimated mean difference between groups in psychotic symptoms was -0.32 (-0.58 to -0.06, P = 0.02) and in negative symptoms was -0.45 (-0.67 to -0.22, P < 0.001), both in favour of integrated treatment. Patients who received integrated treatment had significantly less comorbid substance misuse, better adherence to treatment, and more satisfaction with treatment.
conclusionIntegrated treatment improved clinical outcome and adherence to treatment. The improvement in clinical outcome was consistent at one year and two year follow-ups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.