ArticleAmerican journal of respiratory and critical care medicine2005
Respiratory-related discharge of genioglossus muscle motor units.
Article in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Varied ionic currents underlie functional diversity of hypoglossal motoneurons innervating the superior longitudinalis and genioglossus tongue muscles.The Journal of physiology · 2025Article
- Beyond CPAP: modifying upper airway output for the treatment of OSA.Frontiers in neurology · 2023Review
- Tongue muscle contractile, fatigue, and fiber type properties in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Measurement and State-Dependent Modulation of Hypoglossal Motor Excitability and Responsivity In-Vivo.Scientific reports · 2020Article
- Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract.Pflugers Archiv : European journal of physiology · 2020Article
- Restoring Ventilatory Control Using an Adaptive Bioelectronic System.Journal of neurotrauma · 2019Article
- Muscles of Breathing: Development, Function, and Patterns of Activation.Comprehensive Physiology · 2019Review
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Evaluating the control: minipump implantation and breathing behavior in the neonatal rat.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.Journal of neurophysiology · 2016Article
- Influence of developmental nicotine exposure on spike-timing precision and reliability in hypoglossal motoneurons.Journal of neurophysiology · 2015Article
- Activation of upper airway muscles during breathing and swallowing.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Respiration-related discharge of hyoglossus muscle motor units in the rat.Journal of neurophysiology · 2014Article
- Human hypoglossal motor unit activities in exercise.The Journal of physiology · 2013Article
- Central chemoreceptors: locations and functions.Comprehensive Physiology · 2012Review
- Activities of human genioglossus motor units.Respiratory physiology & neurobiology · 2011Review
- Influence of tongue muscle contraction and transmural pressure on nasopharyngeal geometry in the rat.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Synchronization of presynaptic input to motor units of tongue, inspiratory intercostal, and diaphragm muscles.Journal of neurophysiology · 2011Article
- Article
- Tonically discharging genioglossus motor units show no evidence of rate coding with hypercapnia.Journal of neurophysiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleLittle is known about the respiratory-related discharge properties of motor units driving any of the eight muscles that control the movement, shape, and stiffness of the mammalian tongue.
objectivesTo characterize the respiratory-related discharge of genioglossus motor units as synaptic drive to the hypoglossal motoneuron pool is increased with hypercapnia. MEASUREMENTS: We recorded airflow, genioglossus muscle EMG activity, and the respiratory-related discharge of 30 genioglossus muscle motor units in spontaneously breathing, urethane-anesthetized rats under control conditions and in hypercapnia (inspired CO2: 3, 6, 9, and 12%, 3-5 min at each level). MAIN
resultsAll motor units were active throughout all or most of inspiration. Nine of 30 units showed "preinspiratory" activity (discharge onset within the last 20% of expiration), with continued discharge into inspiration. Six inspiratory units transitioned to a preinspiratory pattern when inspired CO2 exceeded 6%. For the majority of units (23/30), discharge rate increased with hypercapnia, with the maximum increase averaging about 50%. The average variability of interspike intervals within a spike train increased from 33% under baseline conditions to 50% with maximal hypercapnia.
conclusions(1) The discharge pattern of genioglossus muscle motor units can be altered by hypercapnia; (2) most, but not all, genioglossus motor units receive synaptic input from CO2-sensitive chemoreceptors; (3) individual motor units have a wide range of CO2 sensitivities; and (4) hypercapnia significantly increases the variability of motor unit discharge, which may enhance muscle force output.
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Registered trials
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