ArticleProceedings of the National Academy of Sciences of the United States of America2005
RBR3, a member of the retinoblastoma-related family from maize, is regulated by the RBR1/E2F pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 77 citations in OpenAlex.
- Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells.Nature communications · 2026Article
- Analysis of candidate genes identified via genome-wide association analysis of sugar-related traits in maize kernels.The plant genome · 2025Article
- The chromatin accessibility landscape during early maize seed development.The Plant journal : for cell and molecular biology · 2025Article
- Genome-Wide Identification and Evolutionary and Expression Analyses of the Cyclin B Gene Family inPlants (Basel, Switzerland) · 2024Article
- A multi-locus linear mixed model methodology for detecting small-effect QTLs for quantitative traits in MAGIC, NAM, and ROAM populations.Computational and structural biotechnology journal · 2023Article
- Transcriptional analysis ofFrontiers in plant science · 2022Article
- Maize kernel development.Molecular breeding : new strategies in plant improvement · 2021Review
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- ThePlant physiology · 2020Article
- Genome-wide evolutionary characterization and expression analysis of SIAMESE-RELATED family genes in maize.BMC evolutionary biology · 2020Article
- Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.International journal of molecular sciences · 2020Review
- Article
- Cell type specific transcriptional reprogramming of maize leaves during Ustilago maydis induced tumor formation.Scientific reports · 2019Article
- The distribution pattern of endopolyploidy in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Core cell cycle regulatory genes in rice and their expression profiles across the growth zone of the leaf.Journal of plant research · 2015Article
- Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division.Journal of experimental botany · 2014Article
- Article
- Cell cycle control and seed development.Frontiers in plant science · 2014Review
- Expression, regulation and activity of a B2-type cyclin in mitotic and endoreduplicating maize endosperm.Frontiers in plant science · 2014Article
- Cloning and Expression Profiling of the Polycomb Gene, Retinoblastoma-related Protein from Tomato Solanum lycopersicum L.Evolutionary bioinformatics online · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoblastoma-related (RBR) proteins regulate cell division in higher eukaryotes by controlling the adenovirus E2 promoter binding factor (E2F)/dimerization partner (DP) family of transcription factors that regulate expression of many genes involved in cell-cycle progression. We identified a previously undescribed member of the maize RBR family, RBR3, which has the characteristic structure and binding activities of pocket proteins, where interaction depends on a LxCxE motif in the partner proteins and a critical cysteine within the B pocket domain. Like other RBR proteins, RBR3 appears to be regulated by phosphorylation mediated by cyclin-dependent kinases. During endosperm development, RBR3 expression is restricted to the mitotic stage preceding the onset of endoreduplication. This finding suggests a role distinct from RBR1, which is constitutively expressed. Two sites in the RBR3 promoter bind to complexes containing maize E2F1 and DP proteins. Expression of wheat dwarf virus RepA protein, which blocks RBR1 activity and stimulates cell proliferation, dramatically up-regulates RBR3, but not RBR1, RNA in embryogenic maize calli. The results indicate that RBR3 expression is controlled by RBR1 through the activity of E2F/DP and that RBR3 is the maize equivalent of mammalian p107. Furthermore, maize and related grasses might have evolved a compensatory mechanism among distinct types of RBR proteins to ensure robust control of pocket protein activity.
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