Trial reportThe Journal of physiology2005
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01398943 (Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regulation of Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease: A Mechanistic Approach
Who cites it
108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Long-Term Aerobic Exercise Improves Vascular Function Into Old Age: A Systematic Review, Meta-Analysis and Meta Regression of Observational and Interventional Studies.Frontiers in physiology · 2019Pooled it
- The impact of age on vascular smooth muscle function in humans.Journal of hypertension · 2015Pooled it
- No effect of acute tetrahydrobiopterin (BHJournal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Trial
- Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.Journal of the American Heart Association · 2016Trial
- Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Impairments in central cardiovascular function contribute to attenuated reflex vasodilation in aged skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2013Trial
- Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure.Journal of the American College of Cardiology · 2013Trial
- Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.American journal of hypertension · 2012Trial
- Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.Hypertension (Dallas, Tex. : 1979) · 2012Trial
- Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women.American journal of physiology. Heart and circulatory physiology · 2012Trial
- Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults.Clinical science (London, England : 1979) · 2011Trial
- Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.American journal of physiology. Heart and circulatory physiology · 2009Trial
- Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.Circulation · 2009Trial
- Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults.Hypertension (Dallas, Tex. : 1979) · 2008Trial
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Endothelium-dependent dilatation (EDD) is impaired with ageing in sedentary, but not in regularly exercising adults. We tested the hypotheses that differences in tetrahydrobiopterin (BH(4)) bioactivity are key mechanisms explaining the impairment in EDD with sedentary ageing, and the maintenance of EDD with ageing in regularly exercising adults. Brachial artery flow-mediated dilatation (FMD), normalized for local shear stress, was measured after acute oral placebo or BH(4) in young sedentary (YS) (n = 10; 22 +/- 1 years, mean +/- s.e.m.), older sedentary (OS) (n = 9; 62 +/- 2), and older habitually aerobically trained (OT) (n = 12; 66 +/- 1) healthy men. At baseline, FMD was approximately 50% lower in OS versus YS (1.12 +/- 0.09 versus 0.57 +/- 0.09 (Deltamm (dyn cm(-2))) x 10(-2), P < 0.001; 1 dyn = 10(-5) N), but was preserved in OT (0.93 +/- 0.08 (Deltamm (dyn cm(-2))) x 10(-2)). BH4 administration improved FMD by approximately 45% in OS (1.00 +/- 0.10 (Deltamm (dyn cm(-2))) x 10(-2), P < 0.01 versus baseline), but did not affect FMD in YS or OT. Endothelium-independent dilatation neither differed between groups at baseline nor changed with BH4 administration. These results suggest that BH4 bioactivity may be a key mechanism involved in the impairment of conduit artery EDD with sedentary ageing, and the EDD-preserving effect of habitual exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.