ReviewThe Journal of physiology2005
On the peripheral and central chemoreception and control of breathing: an emerging role of ATP.
Review in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 105 citations in OpenAlex.
- Oxytocinergic signalling in the respiratory parafacial region increases the activity of chemosensitive neurons and respiratory output.The Journal of physiology · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Sleep-Disordered Breathing and Central Respiratory Control in Children: A Comprehensive Review.Children (Basel, Switzerland) · 2025Review
- A model to simulate human cardio-respiratory responses to airway obstruction.Frontiers in physiology · 2025Article
- Review
- Silent hypoxia in COVID-19: a gut microbiota connection.Current opinion in physiology · 2021Review
- Inhibition of the hypercapnic ventilatory response by adenosine in the retrotrapezoid nucleus in awake rats.Neuropharmacology · 2018Article
- Review
- On the existence of a central respiratory oxygen sensor.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Three-dimensional architectures of P2X2-/P2X3-immunoreactive afferent nerve terminals in the rat carotid body as revealed by confocal laser scanning microscopy.Histochemistry and cell biology · 2016Article
- Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats.Acta physiologica (Oxford, England) · 2016Article
- Proton detection and breathing regulation by the retrotrapezoid nucleus.The Journal of physiology · 2016Review
- CO2-Induced ATP-Dependent Release of Acetylcholine on the Ventral Surface of the Medulla Oblongata.PloS one · 2016Article
- Article
- Association between polymorphisms in the P2RY1 and SSTR2 genes and sudden infant death syndrome.International journal of legal medicine · 2013Article
- P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Differential sensitivity of brainstem versus cortical astrocytes to changes in pH reveals functional regional specialization of astroglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.The Journal of physiology · 2012Article
- Purinergic modulation of preBötzinger complex inspiratory rhythm in rodents: the interaction between ATP and adenosine.The Journal of physiology · 2011Article
- Ventilatory behavior and carotid body morphology of Brown Norway and Sprague Dawley rats.Respiratory physiology & neurobiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Peripheral and central respiratory chemoreceptors are ultimately responsible for maintenance of constant levels of arterial P(O2), P(CO2) and [H+], protecting the brain from hypoxia and ensuring that the breathing is always appropriate for metabolism. The aim of this discussion is to shed some light on the potential mechanisms of chemosensory transduction - the process which links chemosensory mechanisms to the central nervous mechanisms controlling breathing. Recent experimental data suggest that the purine nucleotide ATP acts as a common mediator of peripheral and central chemosensory transduction (within the carotid body and the medulla oblongata, respectively). In response to a decrease in P(O2) (hypoxia) oxygen-sensitive glomus cells of the carotid body release ATP to activate chemoafferent fibres of the carotid sinus nerve which transmit this information to the brainstem respiratory centres. In response to an increase in P(CO2)/[H+] (hypercapnia) chemosensitive structures located on the ventral surface of the medulla oblongata rapidly release ATP, which acts locally within the medullary respiratory network. The functional role of ATP released at both sites is similar--to evoke adaptive enhancement in breathing. Understanding the mechanisms of ATP release in response to chemosensory stimulation may prove to be essential for further detailed analysis of cellular and molecular mechanisms underlying respiratory chemosensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.