ArticleGenome research2005
Independent intrachromosomal recombination events underlie the pericentric inversions of chimpanzee and gorilla chromosomes homologous to human chromosome 16.
Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species.BMC genomics · 2020Review
- Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing.Genes · 2020Article
- Recurrence of Chromosome Rearrangements and Reuse of DNA Breakpoints in the Evolution of the Triticeae Genomes.G3 (Bethesda, Md.) · 2016Article
- Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering.Molecular biology and evolution · 2016Article
- Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures.Genome research · 2014Article
- The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters.Die Naturwissenschaften · 2014Review
- Pericentric inversion of chromosome 18 in parents leading to a phenotypically normal child with segmental uniparental disomy 18.European journal of human genetics : EJHG · 2011Article
- Human DHX9 helicase unwinds triple-helical DNA structures.Biochemistry · 2010Article
- Article
- A satellite-like sequence, representing a "clone gap" in the human genome, was likely involved in the seeding of a novel centromere in macaque.Chromosoma · 2009Article
- Complex evolution of a Y-chromosomal double homeobox 4 (DUX4)-related gene family in hominoids.PloS one · 2009Article
- Chromosomal evolution of the PKD1 gene family in primates.BMC evolutionary biology · 2008Article
- Reconstructing phylogenies and phenotypes: a molecular view of human evolution.Journal of anatomy · 2008Review
- Phylogenomics of African guenons.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Molecular mechanisms of chromosomal rearrangement during primate evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Chromosomal inversions between human and chimpanzee lineages caused by retrotransposons.PloS one · 2008Article
- Principles of genome evolution in the Drosophila melanogaster species group.PLoS biology · 2007Article
- Structural divergence between the human and chimpanzee genomes.Human genetics · 2007Review
- On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees.Genome biology · 2007Article
- A high-resolution map of synteny disruptions in gibbon and human genomes.PLoS genetics · 2006Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analyses of chromosomal rearrangements that have occurred during the evolution of the hominoids can reveal much about the mutational mechanisms underlying primate chromosome evolution. We characterized the breakpoints of the pericentric inversion of chimpanzee chromosome 18 (PTR XVI), which is homologous to human chromosome 16 (HSA 16). A conserved 23-kb inverted repeat composed of satellites, LINE and Alu elements was identified near the breakpoints and could have mediated the inversion by bringing the chromosomal arms into close proximity with each other, thereby facilitating intrachromosomal recombination. The exact positions of the breakpoints may then have been determined by local DNA sequence homologies between the inversion breakpoints, including a 22-base pair direct repeat. The similarly located pericentric inversion of gorilla (GGO) chromosome XVI, was studied by FISH and PCR analysis. The p- and q-arm breakpoints of the inversions in PTR XVI and GGO XVI were found to occur at slightly different locations, consistent with their independent origin. Further, FISH studies of the homologous chromosomal regions in macaque and orangutan revealed that the region represented by HSA BAC RP11-696P19, which spans the inversion breakpoint on HSA 16q11-12, was derived from the ancestral primate chromosome homologous to HSA 1. After the divergence of orangutan from the other great apes approximately 12 million years ago (Mya), a duplication of the corresponding region occurred followed by its interchromosomal transposition to the ancestral chromosome 16q. Thus, the most parsimonious interpretation is that the gorilla and chimpanzee homologs exhibit similar but nonidentical derived pericentric inversions, whereas HSA 16 represents the ancestral form among hominoids.
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