Trial reportNeuroImage2006
Cytology and functionally correlated circuits of human posterior cingulate areas.
Trial report in NeuroImage, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
208 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Mindfulness in the focus of the neurosciences - The contribution of neuroimaging to the understanding of mindfulness.Frontiers in behavioral neuroscience · 2022Pooled it
- Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity.Cerebral cortex (New York, N.Y. : 1991) · 2019Pooled it
- Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis.Scientific reports · 2019Pooled it
- Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder.BMC psychiatry · 2016Pooled it
- Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies.BioMed research international · 2016Pooled it
- Subspecialization in the human posterior medial cortex.NeuroImage · 2015Pooled it
- Three key regions for supervisory attentional control: evidence from neuroimaging meta-analyses.Neuroscience and biobehavioral reviews · 2015Pooled it
- Pooled it
- Default mode of brain function in monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Pooled it
- Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies.Cerebral cortex (New York, N.Y. : 1991) · 2009Pooled it
- A meta-analytic study of changes in brain activation in depression.Human brain mapping · 2008Pooled it
- 5-HTBiological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects.European archives of psychiatry and clinical neuroscience · 2020Trial
- Neurophysiological differences in the adolescent brain following a single night of restricted sleep - A 7T fMRI study.Developmental cognitive neuroscience · 2018Trial
- Spatial and temporal heterogeneity of neural responses in human posteromedial cortex.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Caffeine alters resting-state functional connectivity measured by blood oxygenation level-dependent MRI.NMR in biomedicine · 2014Trial
- The neural substrates of self-evaluation of mental fatigue: a magnetoencephalography study.PloS one · 2014Trial
- Portraying the unique contribution of the default mode network to internally driven mnemonic processes.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder.Psychiatry research · 2011Trial
- Serotonin modulation of cerebral glucose metabolism in depressed older adults.Biological psychiatry · 2009Trial
148 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Human posterior cingulate cortex (PCC) and retrosplenial cortex (RSC) form the posterior cingulate gyrus, however, monkey connection and human imaging studies suggest that PCC area 23 is not uniform and atlases mislocate RSC. We histologically assessed these regions in 6 postmortem cases, plotted a flat map, and characterized differences in dorsal (d) and ventral (v) area 23. Subsequently, functional connectivity of histologically guided regions of interest (ROI) were assessed in 163 [(18)F]fluorodeoxyglucose human cases with PET. Compared to area d23, area v23 had a higher density and larger pyramids in layers II, IIIc, and Vb and more intermediate neurofilament-expressing neurons in layer Va. Coregisrtration of each case to standard coordinates showed that the ventral branch of the splenial sulci coincided with the border between d/v PCC at -5.4 +/- 0.17 cm from the vertical plane and +1.97 +/- 0.08 cm from the bi-commissural line. Correlation analysis of glucose metabolism using histologically guided ROIs suggested important circuit differences including dorsal and ventral visual stream inputs, interactions between the vPCC and subgenual cingulate cortex, and preferential relations between dPCC and the cingulate motor region. The RSC, in contrast, had restricted correlated activity with pericallosal cortex and thalamus. Visual information may be processed with an orbitofrontal link for synthesis of signals to drive premotor activity through dPCC. Review of the literature in terms of a PCC duality suggests that interactions of dPCC, including area 23d, orient the body in space via the cingulate motor areas, while vPCC interacts with subgenual cortex to process self-relevant emotional and non-emotional information and objects and self-reflection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.