Evidence map›Paper›PMID 16138188›Full record

ArticleThe Journal of clinical investigation2005

Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells.

Miriam J Baron, Dennis L Kasper

Abstract readComment
In one paragraph

Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Miriam J BaronThe Channing Laboratory and the Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Dennis L Kasper

Funding

Group B Strep Alp Protein-Epithelial Cell InteractionK08AI059495 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BARON BARSHAK, MIRIAM · 2004 to 2008
$622k
PREVENTION OF GROUP B STREPTOCOCCAL /GBS/ DISEASE-266025495-266025495N01AI025495 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KASPER, DENNIS L. · 2002 to 2006
–
NIAID NIH HHS AI59495NIAID NIH HHS K08 AI059495NIAID NIH HHS N01 AI025495
6 · The paper itself

Abstract

Group B Streptococcus (GBS) is an important cause of infections, including meningitis. The molecular events underlying its pathogenesis are poorly understood. A study in this issue of the JCI reports that the GBS invasion-associated gene (iagA) contributes to meningeal infection and virulence by facilitating invasion of the cells that compose the blood-brain barrier and of other host cells. The mechanism involved most likely relates to the gene product's role in synthesis of a glycolipid anchor for a bacterial cell-surface entity that interacts directly with host cells.

Indexed as

Bacterial AdhesionBacterial ProteinsFemaleGlycolipidsGlycosylphosphatidylinositolsHumansInfant, NewbornMeningitis, BacterialStreptococcus agalactiaeBacterial ProteinsGlycolipidsGlycosylphosphatidylinositols

Identifiers

PMID16138188
PMCPMC1193890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.