ArticleAtherosclerosis2006
Premature atherosclerosis in HIV positive patients and cumulated time of exposure to antiretroviral therapy (SHIVA study).
Article in Atherosclerosis, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01683656 (ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Prevalence of hypertension among patients aged 50 and older living with human immunodeficiency virus.Medicine · 2019Pooled it
- Cocaine use modifies the association between antiretroviral therapy and endothelial dysfunction among adults with HIV infection.Journal of medical virology · 2019Article
- Atherosclerosis in subjects newly diagnosed with human immunodeficiency virus infection.Bioscience reports · 2018Observational
- Knowledge and perception on type2 diabetes and hypertension among HIV clients utilizing care and treatment services: a cross sectional study from Mbeya and Dar es Salaam regions in Tanzania.BMC public health · 2018Article
- Visceral adipose tissue and carotid intima-media thickness in HIV-infected patients undergoing cART: a prospective cohort study.BMC infectious diseases · 2018Article
- Atherosclerosis is associated with a higher risk of hepatic steatosis in HIV-infected patients.Journal of preventive medicine and hygiene · 2017Article
- Newer perspectives of coronary artery disease in young.World journal of cardiology · 2016Review
- Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction.Free radical biology & medicine · 2016Article
- Cardiovascular Complications of HIV-Associated Immune Dysfunction.Cardiology research and practice · 2015Review
- Magnitude and risk factors of non-communicable diseases among people living with HIV in Tanzania: a cross sectional study from Mbeya and Dar es Salaam regions.BMC public health · 2014Article
- Carotid intima media thickness is associated with body fat abnormalities in HIV-infected patients.BMC infectious diseases · 2014Article
- Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet.Croatian medical journal · 2013Article
- Article
- The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study.Atherosclerosis · 2013Article
- Kaposi's sarcoma-associated herpesvirus infection of endothelial progenitor cells impairs angiogenic activity in vitro.Journal of microbiology (Seoul, Korea) · 2011Article
- Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients.Cardiovascular ultrasound · 2011Article
- Switching antiretroviral therapy to minimize metabolic complications.HIV therapy · 2010Article
- Cardiovascular risk evaluation and antiretroviral therapy effects in an HIV cohort: implications for clinical management: the CREATE 1 study.International journal of clinical practice · 2010Article
- Ultrasound-assessed perirenal fat is related to increased ophthalmic artery resistance index in HIV-1 patients.Cardiovascular ultrasound · 2010Article
- Antiretroviral compounds and cholesterol efflux from macrophages.Atherosclerosis · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the advent of antiretroviral therapy regimens in HIV positive patients, it is crucial to consider their long-term benefits to risk ratios. The responsibility of treatment in premature atherosclerosis is not clear. Thus, the aim of this study is to evaluate the impact of exposure to reverse transcriptase inhibitors (nucleosidic and non-nucleosidic) and to protease inhibitors on the cardiovascular status of an entire hospital based cohort of patients.
methods154 patients were included. Using a linear analysis, we sought an association between the cumulative time of exposure to these three classes of antiretroviral drugs and the carotid intima-media thickness measured by ultrasonography and a cardiovascular composite score.
resultsThe study confirms premature atherosclerosis, which not only correlates with the usual risk factors, such as triglyceride level, but also with protease inhibitor exposure, especially that of lopinavir. Nevertheless as regards current drug exposure, the clinical impact was low: five clinical complications of atherosclerosis and only one out of 35 scintigraphic and ECG exercise tests warranted a coronary angiography which was negative.
conclusionThese data should not lead to the rejection of protease inhibitors but should strengthen the prevention of cardiovascular diseases as an integral part of the management of HIV patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.