ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Alendronate improves vitamin D-resistant osteopenia triggered by gastrectomy in patients with gastric cancer followed long term.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 23 citations in OpenAlex.
- Osteosarcopenia as a prognostic indicator of gastric cancer compared with established nutritional markers.Langenbeck's archives of surgery · 2026Article
- Utility of monthly minodronate for osteoporosis after gastrectomy: Prospective multicenter randomized controlled trials.Annals of gastroenterological surgery · 2021Article
- Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels.Frontiers in pharmacology · 2020Article
- Review
- Influence of gastrectomy on cortical and cancellous bones in rats.Gastroenterology research and practice · 2013Article
- High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy.World journal of gastroenterology · 2007Article
- Changes in vitamin D after gastrectomy.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2007Article
- Osteoporotic Hip Fracture as a Delayed Complication of Bariatric Surgery.Radiology case reports · 2006Article
- A Gender Comparison of Bone Metabolic Changes After Gastric Cancer Surgery: A Prospective Observational Study.In vivo (Athens, Greece)Observational
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Gastrectomy/gastric bypass has been used for patients with gastric cancer, and its application is now expanding to treating patients with morbid obesity, the prevalence of which is increasing worldwide. It is well known that gastrectomy leads to osteopenia, but the underlying pathophysiology and optimum treatments for this disorder have not been delineated. We followed 13 patients who showed progressive osteopenia (bone mineral density T-score<-2.4 SD) after gastrectomy/gastric bypass due to gastric cancer and who were resistant to long-term treatment (mean, 6 years) of active vitamin D3 and prospectively studied the effects of alendronate, a bisphosphonate, on osteopenia-related parameters for 2 years. Oral administration of alendronate in addition to vitamin D3 led to remarkable improvement within 2 years, not only in clinical symptoms, such as radial bone fractures and lumbar pain, but also in parameters for osteopenia, including decreased bone mineral density of the lumbar spine (P<0.01), decreased concentrations of calcium (P<0.05), increased urine levels of deoxypyridinoline (P<0.01), increased serum levels of bone-specific alkaline phosphatase (P<0.01), increased serum levels of osteocalcin (P<0.01), and increased serum levels of intact parathyroid hormone (P<0.05), although body weight did not alter. These results suggest that bisphosphonate may improve osteopenia after gastrectomy/gastric bypass.
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