Evidence map›Paper›PMID 16137373›Full record

ArticleCritical care (London, England)2005

Renal blood flow in sepsis: a complex issue.

Bruce A Molitoris

Abstract readComment
In one paragraph

Article in Critical care (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Renal Hemodynamics in AKI: In Search of New Treatment Targets.Journal of the American Society of Nephrology : JASN · 2016
    Article
  3. Article
  4. Article
  5. Review
  6. Furosemide is associated with acute kidney injury in critically ill patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012
    Article
  7. Surgical sepsis and organ crosstalk: the role of the kidney.The Journal of surgical research · 2011
    Review
  8. Potential interventions in sepsis-related acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN · 2008
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Bruce A MolitorisDivision of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA. bmolitor@iupui.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.

Indexed as

Renal CirculationAnimalsDisease Models, AnimalHemodynamicsHumansModels, BiologicalSepsis

Identifiers

PMID16137373
PMCPMC1269462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.