ArticleHealth and quality of life outcomes2005
Subjective assessments of comorbidity correlate with quality of life health outcomes: initial validation of a comorbidity assessment instrument.
Article in Health and quality of life outcomes, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
154 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- How to assess multimorbidity: a systematic review.Frontiers in public health · 2025Pooled it
- Pooled it
- Measuring multimorbidity beyond counting diseases: systematic review of community and population studies and guide to index choice.BMJ (Clinical research ed.) · 2020Pooled it
- Patient-reported physical activity questionnaires: a systematic review of content and format.Health and quality of life outcomes · 2012Pooled it
- Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide.Annals of family medicinePooled it
- Feasibility of a digital palliative care intervention (Convoy-Pal) for older adults with heart failure and multiple chronic conditions and their caregivers: a waitlist randomized control trial.BMC palliative care · 2024Trial
- A Randomized Controlled Trial Testing the Effects of a Social Needs Navigation Intervention on Health Outcomes and Healthcare Utilization among Medicaid Members with Type 2 Diabetes.International journal of environmental research and public health · 2024Trial
- A pragmatic randomized controlled trial of group transdiagnostic cognitive-behaviour therapy for anxiety disorders in primary care: study protocol.BMC psychiatry · 2018Trial
- Case Management in Primary Care for Frequent Users of Health Care Services: A Mixed Methods Study.Annals of family medicine · 2018Trial
- The relationship between health literacy and quality of life among frequent users of health care services: a cross-sectional study.Health and quality of life outcomes · 2017Trial
- Adapted yoga to improve physical function and health-related quality of life in physically-inactive older adults: a randomised controlled pilot trial.BMC geriatrics · 2017Trial
- Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India.PloS one · 2017Trial
- Functional Comorbidity Index in chronic rhinosinusitis.International forum of allergy & rhinology · 2016Trial
- Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks.Health and quality of life outcomes · 2014Trial
- A mixed-methods pilot study of the acceptability and effectiveness of a brief meditation and mindfulness intervention for people with diabetes and coronary heart disease.Behavioral medicine (Washington, D.C.) · 2014Trial
- Evaluating the integration of chronic disease prevention and management services into primary health care.BMC health services research · 2013Trial
- Case management and self-management support for frequent users with chronic disease in primary care: a pragmatic randomized controlled trial.BMC health services research · 2013Trial
- Influence of an early recovery telehealth intervention on physical activity and functioning after coronary artery bypass surgery among older adults with high disease burden.Heart & lung : the journal of critical careTrial
- Outcome measurement for multiple long-term conditions research across health-care settings - an overview of reviews.BMC medicine · 2026Review
- Gender Differences in Disease Burden, Symptom Burden, and Quality of Life Among People Living With Heart Failure and Multimorbidity: Cross-Sectional Study.Journal of advanced nursing · 2026Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterventions to improve care for persons with chronic medical conditions often use quality of life (QOL) outcomes. These outcomes may be affected by coexisting (comorbid) chronic conditions as well as the index condition of interest. A subjective measure of comorbidity that incorporates an assessment of disease severity may be particularly useful for assessing comorbidity for these investigations.
methodsA survey including a list of 25 common chronic conditions was administered to a population of HMO members age 65 or older. Disease burden (comorbidity) was defined as the number of self-identified comorbid conditions weighted by the degree (from 1 to 5) to which each interfered with their daily activities. We calculated sensitivities and specificities relative to chart review for each condition. We correlated self-reported disease burden, relative to two other well-known comorbidity measures (the Charlson Comorbidity Index and the RxRisk score) and chart review, with our primary and secondary QOL outcomes of interest: general health status, physical functioning, depression screen and self-efficacy.
results156 respondents reported an average of 5.9 chronic conditions. Median sensitivity and specificity relative to chart review were 75% and 92% respectively. QOL outcomes correlated most strongly with disease burden, followed by number of conditions by chart review, the Charlson Comorbidity Index and the RxRisk score.
conclusionSelf-report appears to provide a reasonable estimate of comorbidity. For certain QOL assessments, self-reported disease burden may provide a more accurate estimate of comorbidity than existing measures that use different methodologies, and that were originally validated against other outcomes. Investigators adjusting for comorbidity in studies using QOL outcomes may wish to consider using subjective comorbidity measures that incorporate disease severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.