ReviewFamilial cancer2005
Use of microsatellite instability and immunohistochemistry testing for the identification of individuals at risk for Lynch syndrome.
Review in Familial cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 127 citations in OpenAlex.
- Multivariable prognostic modelling to improve prediction of colorectal cancer recurrence: the PROSPeCT trial.European radiology · 2024Trial
- Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing.General thoracic and cardiovascular surgery · 2025Article
- Colorectal cancers associated with mismatch repair deficiency.Frontiers in medicine · 2025Review
- Current and Future Biomarkers in Esophagogastric Adenocarcinoma.Journal of gastrointestinal cancer · 2024Review
- Microsatellite Status Detection of Colorectal Cancer: Evaluation of Inconsistency between PCR and IHC.Journal of Cancer · 2023Article
- PMS2-associated Lynch syndrome: Past, present and future.Frontiers in oncology · 2023Review
- Quantitative evaluation of MSI testing using NGS detects the imperceptible microsatellite changed caused by MSH6 deficiency.Familial cancer · 2021Article
- Gastrointestinal cancers: current biomarkers in esophageal and gastric adenocarcinoma.Translational gastroenterology and hepatology · 2020Review
- Screening for Lynch syndrome in young Saudi colorectal cancer patients using microsatellite instability testing and next generation sequencing.Familial cancer · 2018Article
- Microsatellite instability and survival in gastric cancer: A systematic review and meta-analysis.Molecular and clinical oncology · 2015Article
- Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.Cancer · 2015Article
- Lynch Syndrome in patients with clear cell and endometrioid cancers of the ovary.Gynecologic oncology · 2014Article
- Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer.Genetic testing and molecular biomarkers · 2014Article
- Molecular alterations and biomarkers in colorectal cancer.Toxicologic pathology · 2014Review
- Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic non-endometrioid carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2013Article
- The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.Familial cancer · 2013Review
- Application of Immunohistochemistry and Molecular Diagnostics to Clinically Relevant Problems in Endometrial Cancer Bojana Djordjevic, Shannon Westin, Russell R. Broaddus.Surgical pathology clinics · 2012Article
- Lynch syndrome in a predominantly Afrocentric population: a clinicopathological and genetic study.Canadian journal of surgery. Journal canadien de chirurgie · 2012Article
- Article
- Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients.World journal of gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is now generally recognized that a specific subset of those patients clinically defined as having hereditary non polyposis colon cancer (HNPCC) have germline mutations in any one of several genes involved in DNA mismatch repair (MMR). This important subset of HNPCC families is now defined as having Lynch syndrome. A considerable amount of data has shown that tumors from patients with Lynch syndrome have characteristic features resulting from the underlying molecular involvement of defective MMR, that is, the presence of microsatellite instability (MSI) and the absence of MMR protein expression by immunohistochemistry (IHC). As a result, identifying patients with Lynch syndrome can now be accomplished by testing tumors for these tumor-related changes. Together, MSI and IHC are powerful tools that help identify individuals at risk for having Lynch syndrome and to distinguish these cases from HNPCC cases with other hereditary gene defects. Furthermore, IHC analysis provides valuable clues as to which MMR gene is mutated, allowing for comprehensive mutational analyses of that gene. Here, we discuss the current and historical perspectives regarding MSI and IHC analyses in tumors from sporadic colon cancer and from patients with Lynch syndrome. Given this background, we also provide a testing strategy for the identification of patients at risk for Lynch syndrome and subsequent gene testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.