ReviewFamilial cancer2005
The tumor spectrum in the Lynch syndrome.
Review in Familial cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 102 citations in OpenAlex.
- [Secondary malignant neoplasms with underlying Lynch syndrome and coincidental ulcerative colitis].Chirurgie (Heidelberg, Germany) · 2025Article
- Case report: Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, associated with a germline mutation inFrontiers in oncology · 2022Article
- MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer.Prostate cancer and prostatic diseases · 2021Article
- Review
- Review
- Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature.World journal of clinical cases · 2019Article
- Comprehensive mismatch repair gene panel identifies variants in patients with Lynch-like syndrome.Molecular genetics & genomic medicine · 2019Article
- Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- Screening for susceptibility genes in hereditary non-polyposis colorectal cancer.Oncology letters · 2018Article
- Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome.JCO precision oncology · 2018Article
- Genetic anticipation in Swedish Lynch syndrome families.PLoS genetics · 2017Article
- Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.Surgery today · 2017Article
- Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?Virchows Archiv : an international journal of pathology · 2017Article
- Genetic and molecular changes in ovarian cancer.Cancer biology & medicine · 2016Article
- Fertility after young-onset colorectal cancer: a study of subjects with Lynch syndrome.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2015Article
- Considerations and management of a patient with three metachronous cancers in association with Lynch syndrome and ileal Crohn's disease: A case report.International journal of surgery case reports · 2015Article
- Fertility and apparent genetic anticipation in Lynch syndrome.Familial cancer · 2014Article
- No evidence of genetic anticipation in a large family with Lynch syndrome.Familial cancer · 2014Article
- Mismatch repair deficiency screening via immunohistochemical staining in young Asians with colorectal cancers.World journal of surgery · 2013Article
- BRAF mutation in multiple primary cancer with colorectal cancer and stomach cancer.Gastroenterology report · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Colorectal and endometrial cancer are the characteristic tumors of the Lynch syndrome. We reviewed the available evidence on the occurrence of other types of cancer in the syndrome, aiming to identify those types that can be included in the tumor spectrum, based on this evidence. We chose to define the tumor spectrum as comprising the cancers for which Lynch syndrome patients are at elevated risk. We found sufficiently strong and consistent evidence to include gastric cancer, small bowel cancer, hepatobiliary tract cancer, upper urologic tract cancer, ovarian cancer, and brain tumors in this spectrum, in addition to colorectal and endometrial cancer. We predict that the spectrum will expand as additional studies are reported, especially as prospective studies of mutation carriers are completed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.